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Chronic hepatitis B virus infection

MedGen UID:
99834
•Concept ID:
C0524909
•
Disease or Syndrome
Synonyms: Chronic Hepatitis B; Chronic Hepatitis B Virus Infection; Hepatitis B Virus Infection, Chronic; Hepatitis B, Chronic
SNOMED CT: Chronic type B viral hepatitis (61977001); Chronic viral hepatitis B (61977001)
 
Monarch Initiative: MONDO:0005366

Definition

Chronic form of hepatitis B infection. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic hepatitis B virus infection

Professional guidelines

PubMed

AGA Clinical Practice Update on Pregnancy-Related Gastrointestinal and Liver Disease: Expert Review.
Kothari S, Afshar Y, Friedman LS, Ahn J
Gastroenterology 2024 Oct;167(5):1033-1045. Epub 2024 Aug 12 doi: 10.1053/j.gastro.2024.06.014. PMID: 39140906
Immune response and treatment targets of chronic hepatitis B virus infection: innate and adaptive immunity.
Zheng P, Dou Y, Wang Q
Front Cell Infect Microbiol 2023;13:1206720. Epub 2023 Jun 22 doi: 10.3389/fcimb.2023.1206720. PMID: 37424786Free PMC Article
Extending treatment eligibility for chronic hepatitis B virus infection.
McNaughton AL, Lemoine M, van Rensburg C, Matthews PC
Nat Rev Gastroenterol Hepatol 2021 Mar;18(3):146-147. doi: 10.1038/s41575-020-00398-x. PMID: 33323992

Recent clinical studies

Etiology

Immune response and treatment targets of chronic hepatitis B virus infection: innate and adaptive immunity.
Zheng P, Dou Y, Wang Q
Front Cell Infect Microbiol 2023;13:1206720. Epub 2023 Jun 22 doi: 10.3389/fcimb.2023.1206720. PMID: 37424786Free PMC Article
Screening and Testing for Hepatitis B Virus Infection: CDC Recommendations - United States, 2023.
Conners EE, Panagiotakopoulos L, Hofmeister MG, Spradling PR, Hagan LM, Harris AM, Rogers-Brown JS, Wester C, Nelson NP; Contributors
MMWR Recomm Rep 2023 Mar 10;72(1):1-25. doi: 10.15585/mmwr.rr7201a1. PMID: 36893044Free PMC Article
Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response.
Shen Y, Wu SD, Chen Y, Li XY, Zhu Q, Nakayama K, Zhang WQ, Weng CZ, Zhang J, Wang HK, Wu J, Jiang W
Gut Microbes 2023 Jan-Dec;15(1):2155018. doi: 10.1080/19490976.2022.2155018. PMID: 36519342Free PMC Article
Chronic hepatitis B virus infection.
Seto WK, Lo YR, Pawlotsky JM, Yuen MF
Lancet 2018 Nov 24;392(10161):2313-2324. doi: 10.1016/S0140-6736(18)31865-8. PMID: 30496122
Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013.
Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ
Lancet 2015 Oct 17;386(10003):1546-55. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)61412-X. PMID: 26231459

Diagnosis

Serum HBV RNA: a promising biomarker for blood product safety screening and enhanced diagnostic efficiency in chronic hepatitis B virus infection.
Yu S, Guo Y, Zhang C
Front Public Health 2023;11:1248878. Epub 2023 Aug 31 doi: 10.3389/fpubh.2023.1248878. PMID: 37719720Free PMC Article
Screening and Testing for Hepatitis B Virus Infection: CDC Recommendations - United States, 2023.
Conners EE, Panagiotakopoulos L, Hofmeister MG, Spradling PR, Hagan LM, Harris AM, Rogers-Brown JS, Wester C, Nelson NP; Contributors
MMWR Recomm Rep 2023 Mar 10;72(1):1-25. doi: 10.15585/mmwr.rr7201a1. PMID: 36893044Free PMC Article
Chronic hepatitis B virus infection and fibrosis: novel non-invasive approaches for diagnosis and risk stratification.
Stalla F, Armandi A, Marinoni C, Fagoonee S, Pellicano R, Caviglia GP
Minerva Gastroenterol (Torino) 2022 Sep;68(3):306-318. Epub 2021 Apr 19 doi: 10.23736/S2724-5985.21.02911-9. PMID: 33871225
A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma.
Luo P, Yin P, Hua R, Tan Y, Li Z, Qiu G, Yin Z, Xie X, Wang X, Chen W, Zhou L, Wang X, Li Y, Chen H, Gao L, Lu X, Wu T, Wang H, Niu J, Xu G
Hepatology 2018 Feb;67(2):662-675. Epub 2018 Jan 2 doi: 10.1002/hep.29561. PMID: 28960374Free PMC Article
Elevated alpha-fetoprotein: differential diagnosis - hepatocellular carcinoma and other disorders.
Wong RJ, Ahmed A, Gish RG
Clin Liver Dis 2015 May;19(2):309-23. Epub 2015 Feb 27 doi: 10.1016/j.cld.2015.01.005. PMID: 25921665

Therapy

Efficacy and safety of the siRNA JNJ-73763989 and the capsid assembly modulator JNJ-56136379 (bersacapavir) with nucleos(t)ide analogues for the treatment of chronic hepatitis B virus infection (REEF-1): a multicentre, double-blind, active-controlled, randomised, phase 2b trial.
Yuen MF, Asselah T, Jacobson IM, Brunetto MR, Janssen HLA, Takehara T, Hou JL, Kakuda TN, Lambrecht T, Beumont M, Kalmeijer R, Guinard-Azadian C, Mayer C, Jezorwski J, Verbinnen T, Lenz O, Shukla U, Biermer M; REEF-1 Study Group
Lancet Gastroenterol Hepatol 2023 Sep;8(9):790-802. Epub 2023 Jul 10 doi: 10.1016/S2468-1253(23)00148-6. PMID: 37442152
B-Clear Phase 2b Study Design: Establishing the Efficacy and Safety of Bepirovirsen in Patients with Chronic Hepatitis B Virus Infection.
Cremer J, Elston R, Campbell FM, Kendrick S, Paff M, Quinn G, Theodore D
Adv Ther 2023 Sep;40(9):4101-4110. Epub 2023 Jul 1 doi: 10.1007/s12325-023-02531-z. PMID: 37393402Free PMC Article
Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response.
Shen Y, Wu SD, Chen Y, Li XY, Zhu Q, Nakayama K, Zhang WQ, Weng CZ, Zhang J, Wang HK, Wu J, Jiang W
Gut Microbes 2023 Jan-Dec;15(1):2155018. doi: 10.1080/19490976.2022.2155018. PMID: 36519342Free PMC Article
Extending treatment eligibility for chronic hepatitis B virus infection.
McNaughton AL, Lemoine M, van Rensburg C, Matthews PC
Nat Rev Gastroenterol Hepatol 2021 Mar;18(3):146-147. doi: 10.1038/s41575-020-00398-x. PMID: 33323992
Chronic hepatitis B virus infection.
Seto WK, Lo YR, Pawlotsky JM, Yuen MF
Lancet 2018 Nov 24;392(10161):2313-2324. doi: 10.1016/S0140-6736(18)31865-8. PMID: 30496122

Prognosis

Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response.
Shen Y, Wu SD, Chen Y, Li XY, Zhu Q, Nakayama K, Zhang WQ, Weng CZ, Zhang J, Wang HK, Wu J, Jiang W
Gut Microbes 2023 Jan-Dec;15(1):2155018. doi: 10.1080/19490976.2022.2155018. PMID: 36519342Free PMC Article
A single-cell atlas of diffuse large B cell lymphoma.
Ye X, Wang L, Nie M, Wang Y, Dong S, Ren W, Li G, Li ZM, Wu K, Pan-Hammarström Q
Cell Rep 2022 Apr 19;39(3):110713. doi: 10.1016/j.celrep.2022.110713. PMID: 35443163
Atypical course of infective endocarditis in a patient with complex congenital heart disease, chronic hepatitis B virus infection, and splenic marginal zone lymphoma.
Szczepanek E, Kostkiewicz M, Małecka B, Giza A, Gałązka K, Tomkiewicz-Pająk L
Pol Arch Intern Med 2020 Aug 27;130(7-8):697-699. Epub 2020 May 19 doi: 10.20452/pamw.15367. PMID: 32426956
Epigenetic modulation in chronic hepatitis B virus infection.
Dandri M
Semin Immunopathol 2020 Apr;42(2):173-185. Epub 2020 Mar 17 doi: 10.1007/s00281-020-00780-6. PMID: 32185454Free PMC Article
Elevated alpha-fetoprotein: differential diagnosis - hepatocellular carcinoma and other disorders.
Wong RJ, Ahmed A, Gish RG
Clin Liver Dis 2015 May;19(2):309-23. Epub 2015 Feb 27 doi: 10.1016/j.cld.2015.01.005. PMID: 25921665

Clinical prediction guides

Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people.
Liu Z, Lin C, Mao X, Guo C, Suo C, Zhu D, Jiang W, Li Y, Fan J, Song C, Zhang T, Jin L, De Martel C, Clifford GM, Chen X
Gut 2023 Nov 24;72(12):2354-2363. doi: 10.1136/gutjnl-2023-330691. PMID: 37798085Free PMC Article
Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B.
Ji D, Chen Y, Bi J, Shang Q, Liu H, Wang JB, Tan L, Wang J, Chen Y, Li Q, Long Q, Song L, Jiang L, Xiao G, Yu Z, Chen L, Wang X, Chen D, Li Z, Dong Z, Yang Y
J Hepatol 2022 Dec;77(6):1515-1524. Epub 2022 Aug 18 doi: 10.1016/j.jhep.2022.07.018. PMID: 35985545
A single-cell atlas of diffuse large B cell lymphoma.
Ye X, Wang L, Nie M, Wang Y, Dong S, Ren W, Li G, Li ZM, Wu K, Pan-Hammarström Q
Cell Rep 2022 Apr 19;39(3):110713. doi: 10.1016/j.celrep.2022.110713. PMID: 35443163
Chronic Hepatitis C Virus Infection and Depression.
Adinolfi LE, Nevola R, Rinaldi L, Romano C, Giordano M
Clin Liver Dis 2017 Aug;21(3):517-534. Epub 2017 Apr 25 doi: 10.1016/j.cld.2017.03.007. PMID: 28689590
Elevated alpha-fetoprotein: differential diagnosis - hepatocellular carcinoma and other disorders.
Wong RJ, Ahmed A, Gish RG
Clin Liver Dis 2015 May;19(2):309-23. Epub 2015 Feb 27 doi: 10.1016/j.cld.2015.01.005. PMID: 25921665

Recent systematic reviews

Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people.
Liu Z, Lin C, Mao X, Guo C, Suo C, Zhu D, Jiang W, Li Y, Fan J, Song C, Zhang T, Jin L, De Martel C, Clifford GM, Chen X
Gut 2023 Nov 24;72(12):2354-2363. doi: 10.1136/gutjnl-2023-330691. PMID: 37798085Free PMC Article
Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997-2022: A Systematic Review and Meta-Analysis.
Yendewa GA, Wang GM, James PB, Massaquoi SPE, Yendewa SA, Ghazawi M, Babawo LS, Ocama P, Russell JBW, Deen GF, Sahr F, Kabba M, Tatsuoka C, Lakoh S, Salata RA
Am J Trop Med Hyg 2023 Jul 5;109(1):105-114. Epub 2023 May 22 doi: 10.4269/ajtmh.22-0711. PMID: 37217165Free PMC Article
Chronic hepatitis B virus infection and preterm labor(birth) in pregnant women-an updated systematic review and meta-analysis.
Ma X, Sun D, Li C, Ying J, Yan Y
J Med Virol 2018 Jan;90(1):93-100. Epub 2017 Sep 12 doi: 10.1002/jmv.24927. PMID: 28851115
Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis.
Leroi C, Adam P, Khamduang W, Kawilapat S, Ngo-Giang-Huong N, Ongwandee S, Jiamsiri S, Jourdain G
Int J Infect Dis 2016 Oct;51:36-43. Epub 2016 Aug 28 doi: 10.1016/j.ijid.2016.08.017. PMID: 27580678
Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013.
Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ
Lancet 2015 Oct 17;386(10003):1546-55. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)61412-X. PMID: 26231459

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