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Binding affinity to human biotinylated NSD2 (208 to 368 residues) expressed in Escherichia coli BL21(DE3) by SPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to Avi-tagged WHSC1 (941 to 1240 residues) (unknown origin) by SPR assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of WHSC1 (941 to 1240 residues) (unknown origin) using biotinylated-RLARRGGVKRISGLI as substrate incubated for 120 mins in presence of [3H]-SAM by Topcount scintillation counting method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MMSET (unknown origin)
Inhibition of NSD2 in human KMS-11-Par cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISA
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of NSD2 in human CGTH-W-1 cells assessed as reduction in H3K36me2 level incubated for 72 hrs by ELISA
Inhibition of NSD2 (unknown origin)
Assay data:6 Active, 6 Tested
Inhibition of recombinant NSD2-SET (unknown origin) expressed in Escherichia coli BL21 using H3K36 as substrate preincubated for 20 mins followed by SAM addition and measured after 120 mins by colorimetric assay
Inhibition of NSD2 (unknown origin) using H3K36 as substrate
Assay data:2 Tested
Inhibition of 15N-labeled NSD2 (953 to 1240 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 using H3K36 as substrate incubated for 60 mins by Alphascreen assay
Assay data:2 Active, 3 Tested
Inhibition of human NSD2 SET domain using histone H3 as substrate assessed as reduction in H3K36 methylation
Inhibition of N-terminal polyhistidine-tagged human NSD2 expressed in baculovirus infected insect cell using SAM as substrate preincubated for 20 mins followed by substrate addition measured after 1 hrs by hotspot assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of N-terminal GST-tagged human NSD2 (941 to 1240 residues ) expressed in Escherichia coli using 3[H] SAM as substrate measured after 30 mins by biochemical assay
Inhibition of human NSD2 SET domain assessed as reduction in H3K36 methylation
Inhibition of human NSD2 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysis
Assay data:1 Active, 3 Tested
Induction of degradation of NSD2 in human U2OS cells
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Induction of degradation of NSD2 in human U2OS cells assessed as maximum degradation relative to control
Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant by SPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of NSD2 T1150A mutant (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of NSD2 E1099K mutant (unknown origin)
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