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Selectivity interaction (Eurofins CEREP Diversity Profile (receptors and ion channels)) EUB0000279b KCNN1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activity against K+/SKCA in the Eurofins Panlabs screen (BI) by Radioactive Assay
Inhibitor of K+/CA+/R in the Eurofins SafetyScreen44 (BI) by Radioactive Assay (Old_Cerep_23)
Displacement of [125I]apamin from SK3 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis
Displacement of [125I]apamin from human SK3 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Displacement of [125I]apamin from human SK2 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis
Activation of SK3 (unknown origin) expressed in HEK293 cells coexpressing CaM/GFP in presence of Ca2+ by electrophysiological method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Activation of SK1 (unknown origin) expressed in HEK293 cells coexpressing CaM/GFP in presence of Ca2+ by electrophysiological method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Activation of SK3 (unknown origin) expressed in HEK293 cells coexpressing CaM/GFP in presence of Ca2+ by electrophysiological method relative to control
Activation of SK1 (unknown origin) expressed in HEK293 cells coexpressing CaM/GFP at 100 uM in presence of Ca2+ by electrophysiological method
Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp method relative to control
Positive modulation of SK3 in HEK293 cells in presence of Ca2+ by patch-clamp method relative to control
Positive modulation of SK3 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Positive modulation of SK2 (unknown origin)
Positive modulation of SK1 (unknown origin)
Positive modulation of SK3 in HEK293 cells in presence of Ca2+ by patch-clamp method
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp method
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Positive modulation of SK1 in HEK293 cells in presence of Ca2+ by patch-clamp method
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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