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% Enzyme Activity of MMP12 in the Reaction Biology protease panel at 1.0 M
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr-(Dnp)-Ala-Arg-NH2 as substrate preincubated with compound for 15 mins followed by substrate addition and measured after 1 hrs by fluorescence based analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant MMP-12 (17 to 470 residues) Val97Leu mutant expressed in NS0 cells using (7-methoxycoumarin-4-y1)-acetyl-Pro-Leu-Gly-Leu-[3-(2,4-dinitropheny1)-L-2,3-diaminopropionyl]-Ala-Arg-NH2 as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured after 10 mins by fluorescence based analysis
Assay data:16 Active, 14 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant MMP12 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 15 mins followed by substrate addition and measured after 120 mins by fluorescence based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human recombinant MMP12 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 10 to 15 mins followed by substrate addition and measured after 60 to 120 mins by fluorescence based assay
Assay data:14 Active, 13 Activity ≤ 1 µM, 15 Tested
Inhibition of human MMP-12 relative to control
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human MMP-12
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of MMP12 (unknown origin) assessed as inhibition constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of MMP12 (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of MMP12 (unknown origin) by FRET assay
Assay data:1 Active, 1 Tested
Inhibition of MMP-12 (unknown origin) at 20 uM by fluorometric assay
Assay data:1 Tested
Inhibition of MMP-12 (unknown origin)
Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins by fluorescence based analysis
MMP Inhibitory Assay from US Patent US11673884: "Matrix metalloproteinase (MMP) inhibitors and methods of use thereof"
Assay data:12 Active, 9 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Selectivity interaction (MMPs panel (FRET assay)) EUB0000730a MMP12
SummaryRelated BioAssays by Target
Selectivity interaction (MMPs panel (Panlabs panel, Bayer)) EUB0000725a MMP12
Affinity Biochemical interaction (Biochemical assay (inhibition of human macrophage elastase (HME/hMMP-12), addition of 2% BSA)) EUB0000728a MMP12
Affinity Biochemical interaction (Biochemical assay (inhibition of human macrophage elastase (HME/hMMP-12), addition of 2% BSA)) EUB0000725a MMP12
Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay
Assay data:29 Active, 1 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 29 Tested
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