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Binding affinity to Cbx5 (unknown origin) assessed as fold change in protein upregulation at 200 uM preincubated for 2 hrs followed by pronase addition and measured after 30 mins by coomassie blue staining based SDS-PAGE gel analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to CBX1 (unknown origin) assessed as dissociation constant by fluorescence polarization analysis
Assay data:4 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to CBX3 chromodomain (unknown origin) by ITC method
Binding affinity to CBX1 chromodomain (unknown origin) by ITC method
Binding affinity to CBX5 chromodomain (unknown origin) by ITC method
Antagonist activity at recombinant human N-terminal His-tagged CBX5 chromodomain (18 to 75 residues) expressed in Escherichia coli Rosetta BL21(DE3)pLysS using ARTKQTARK(Me3)STGGKAPRKQL-K(Biotin)-NH2 measured after 30 mins by AlphaScreen assay
Assay data:1 Active, 47 Tested
Binding affinity to 15N-labeled CBX5ChD (18 to 75 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells at 200 uM by 1H-15N HSQC NMR spectroscopy
Binding affinity to 15N-labeled CBX3ChD (29 to 86 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells at 200 uM by 1H-15N HSQC NMR spectroscopy
Binding affinity to 15N-labeled CBX1ChD (20 to 73 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells at 200 uM by 1H-15N HSQC NMR spectroscopy
Binding affinity to N-terminal His6-tagged human CBX1 (20 to 73 residues) expressed in Escherichia coli BL21 using FITC-peptide-3 as competitive binding probe by fluorescence polarization assay
Assay data:1 Active, 3 Tested
Binding affinity to CBX1 (unknown origin) by isothermal titration calorimetry assay
Assay data:8 Tested
HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails
Assay data:2150 Active, 3 Activity ≤ 1 nM, 683 Activity ≤ 1 µM, 387034 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Probe Summary Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails
Assay data:186 Active, 3 Activity ≤ 1 nM, 104 Activity ≤ 1 µM, 1280 Tested
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