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Inhibition of JMJD3 (unknown origin) by Alphascreen assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed Citation
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of KDM5B (unknown origin)
Assay data:23 Active, 16 Activity ≤ 1 µM, 29 Tested
Affinity Biochemical interaction (AlphaLISA based assay) EUB0000217b KDM6A/UTX
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Inhibition of TNF release (in LPS stimulated human macrophages derived from PBMC)) EUB0000217b KDM6A/UTX
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling
Assay data:1740 Active, 2530 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Inhibition of KDM5A in human MCF7 cells assessed as effect on H3K27me3 methylation levels at 1 to 10 uM after 30 hrs by Western blot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of KDM5A in human MCF7 cells assessed as effect on H3K4me3 methylation levels at 1 to 10 uM after 30 hrs by Western blot analysis
Diffuse intrinsic pontine glioma (SU-DIPG-XXV) cell line screen of MIPE5.0 library: viability qHTS assay using CellTiter-Fluor
Assay data:484 Active, 2480 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
Diffuse intrinsic pontine glioma (JHH-DIPG-1) cell line screen of MIPE5.0 library: viability qHTS assay using CellTiter-Glo
Assay data:784 Active, 2480 Tested
Diffuse intrinsic pontine glioma (SU-DIPG-XXV) cell line screen of MIPE5.0 library: viability qHTS assay using CellTiter-Glo
Assay data:988 Active, 2480 Tested
Diffuse intrinsic pontine glioma (SU-DIPG-XIII) cell line screen of MIPE5.0 library: viability qHTS assay using CellTiter-Glo
Assay data:702 Active, 2480 Tested
Diffuse intrinsic pontine glioma (SU-DIPG-XVII) cell line screen of MIPE5.0 library: viability qHTS assay using CellTiter-Glo
Assay data:889 Active, 2480 Tested
Human lysine demethylase 6A (1.14.11.- Histone demethylases)
Assay data:2 Active, 2 Tested
Human lysine demethylase 5B (1.14.11.- Histone demethylases)
Assay data:3 Active, 3 Tested
Human lysine demethylase 6B (1.14.11.- Histone demethylases)
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