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Select item 98754681.

A novel mutation in the proteoglycan 4 gene causing CACP syndrome: two sisters report

İlknur Bağrul, Serdar Ceylaner, Yasemin Tasci Yildiz, Serife Tuncez, Elif Arslanoglu Aydin, Esra Bağlan, Semanur Ozdel, Mehmet Bülbül

Pediatr Rheumatol Online J. 2023; 21: 8. Published online 2023 Jan 24. doi: 10.1186/s12969-023-00793-z

PMCID:: PMC9875468

Article PDF–1.1M

Select item 84911692.

Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation

Nikhil G. Menon, Ruchi Goyal, Carolina Lema, Paige S. Woods, Adam P. Tanguay, Alyssa A. Morin, Nabangshu Das, Gregory D. Jay, Roman J. Krawetz, Antoine Dufour, Linda H. Shapiro, Rachel L. Redfern, Mallika Ghosh, Tannin A. Schmidt

Exp Eye Res. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Exp Eye Res. 2021 Jul; 208: 108628. Published online 2021 May 25. doi: 10.1016/j.exer.2021.108628

PMCID:: PMC8491169

Article PDF–1.6M

Select item 82240643.

Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification

Till Seime, Asim Cengiz Akbulut, Moritz Lindquist Liljeqvist, Antti Siika, Hong Jin, Greg Winski, Rick H. van Gorp, Eva Karlöf, Mariette Lengquist, Andrew J. Buckler, Malin Kronqvist, Olivia J. Waring, Jan H. N. Lindeman, Erik A. L. Biessen, Lars Maegdefessel, Anton Razuvaev, Leon J. Schurgers, Ulf Hedin, Ljubica Matic

Cells. 2021 Jun; 10(6): 1276. Published online 2021 May 21. doi: 10.3390/cells10061276

PMCID:: PMC8224064

Article PDF–8.8M

Select item 67147204.

Inflammatory Biomarker Profiling in Total Joint Arthroplasty and Its Relevance to Circulating Levels of Lubricin, a Novel Proteoglycan

Kevin Galicia, Chase Thorson, Andrew Banos, Matthew Rondina, William Hopkinson, Debra Hoppensteadt, Jawed Fareed

Clin Appl Thromb Hemost. 2018 Sep; 24(6): 950–959. Published online 2018 Apr 22. doi: 10.1177/1076029618765090

PMCID:: PMC6714720

Article PDF–428K

Select item 44654655.

Does intra-articular fracture change the lubricant content of synovial fluid?

Hasan H. Ceylan, Mehmet Erdil, Gokhan Polat, Deniz Kara, Elif Kilic, Abdurrahim Kocyigit, Ibrahim Tuncay

J Orthop Surg Res. 2015; 10: 89. Published online 2015 Jun 3. doi: 10.1186/s13018-015-0232-6

PMCID:: PMC4465465

Article PDF–793K

Select item 42564926.

The O-glycomap of Lubricin, a Novel Mucin Responsible for Joint Lubrication, Identified by Site-specific Glycopeptide Analysis

Liaqat Ali, Sarah A. Flowers, Chunsheng Jin, Eric Paul Bennet, Anna-Karin H. Ekwall, Niclas G. Karlsson

Mol Cell Proteomics. 2014 Dec; 13(12): 3396–3409. Published online 2014 Sep 3. doi: 10.1074/mcp.M114.040865

PMCID:: PMC4256492

Article PDF–971K

Select item 38956427.

CACP syndrome: identification of five novel mutations and of the first case of UPD in the largest European cohort

Sara Ciullini Mannurita, Marina Vignoli, Lucia Bianchi, Anuela Kondi, Valeria Gerloni, Luciana Breda, Rebecca ten Cate, Maria Alessio, Angelo Ravelli, Fernanda Falcini, Eleonora Gambineri

Eur J Hum Genet. 2014 Feb; 22(2): 197–201. Published online 2013 Jun 12. doi: 10.1038/ejhg.2013.123

PMCID:: PMC3895642

Article PDF–678K

Select item 34762608.

Human Synovial Lubricin Expresses Sialyl Lewis x Determinant and Has L-selectin Ligand Activity

Chunsheng Jin, Anna-Karin Hultgård Ekwall, Johan Bylund, Lena Björkman, Ruby P. Estrella, John M. Whitelock, Thomas Eisler, Maria Bokarewa, Niclas G. Karlsson

J Biol Chem. 2012 Oct 19; 287(43): 35922–35933. Published online 2012 Aug 28. doi: 10.1074/jbc.M112.363119

PMCID:: PMC3476260

Article PDF–1.3M

Select item 32034769.

Lubricin is expressed in chondrocytes derived from osteoarthritic cartilage encapsulated in poly (ethylene glycol) diacrylate scaffold

G. Musumeci, C. Loreto, M.L. Carnazza, F. Coppolino, V. Cardile, R. Leonardi

Eur J Histochem. 2011 Sep 21; 55(3): e31. Published online 2011 Aug 27. doi: 10.4081/ejh.2011.e31

PMCID:: PMC3203476

Article PDF–925K

Select item 278997410.

Decreased Lubricin Concentrations and Markers of Joint Inflammation in Synovial Fluids from Patients with Anterior Cruciate Ligament Injury

KA Elsaid, BC Fleming, HL Oksendahl, JT Machan, PD Fadale, MJ Hulstyn, R Shalvoy, GD Jay

Arthritis Rheum. Author manuscript; available in PMC 2009 Dec 8.

Published in final edited form as: Arthritis Rheum. 2008 Jun; 58(6): 1707–1715. doi: 10.1002/art.23495

PMCID:: PMC2789974

Article PDF–339K

Select item 185107611.

The role of lubricin in the mechanical behavior of synovial fluid

G. D. Jay, J. R. Torres, M. L. Warman, M. C. Laderer, K. S. Breuer

Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15): 6194–6199. Published online 2007 Apr 2. doi: 10.1073/pnas.0608558104

PMCID:: PMC1851076

Article PDF–794K

Select item 114456912.

The molecular structure and lubricating activity of lubricin isolated from bovine and human synovial fluids.

D A Swann, F H Silver, H S Slayter, W Stafford, E Shore

Biochem J. 1985 Jan 1; 225(1): 195–201. doi: 10.1042/bj2250195

PMCID:: PMC1144569

Article PDF–838K

Select item 872504913.

Recombinant Human Proteoglycan 4 Regulates Phagocytic Activation of Monocytes and Reduces IL-1β Secretion by Urate Crystal Stimulated Gout PBMCs

Sandy ElSayed, Gregory D. Jay, Ralph Cabezas, Marwa Qadri, Tannin A. Schmidt, Khaled A. Elsaid

Front Immunol. 2021; 12: 771677. Published online 2021 Dec 21. doi: 10.3389/fimmu.2021.771677

PMCID:: PMC8725049

Article PDF–5.1M

Select item 799530014.

Interrelationship of MMP-9, Proteoglycan-4, and Inflammation in Osteoarthritis Patients Undergoing Total Hip Arthroplasty

Hannah Slovacek, Rajan Khanna, Pavel Poredos, Peter Poredos, Mateja Jezovnik, Debra Hoppensteadt, Jawed Fareed, William Hopkinson

Clin Appl Thromb Hemost. 2021 Jan-Dec; 27: 1076029621995569. Published online 2021 Mar 23. doi: 10.1177/1076029621995569

PMCID:: PMC7995300

Article PDF–437K

Select item 768100615.

Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking

Sarah A. Flowers, Kristina A. Thomsson, Liaqat Ali, Shan Huang, Yolanda Mthembu, Suresh C. Regmi, Jan Holgersson, Tannin A. Schmidt, Ola Rolfson, Lena I. Björkman, Martina Sundqvist, Anna Karlsson-Bengtsson, Gregory D. Jay, Thomas Eisler, Roman Krawetz, Niclas G. Karlsson

J Biol Chem. 2020 Nov 20; 295(47): 16023–16036. Published online 2020 Sep 14. doi: 10.1074/jbc.RA120.012882

PMCID:: PMC7681006

Article PDF–1.5M

Select item 617103816.

cAMP attenuates TGF-β’s profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4

Marwa M. Qadri, Gregory D. Jay, Rennolds S. Ostrom, Ling X. Zhang, Khaled A. Elsaid

Am J Physiol Cell Physiol. 2018 Sep 1; 315(3): C432–C443. Published online 2018 Jun 13. doi: 10.1152/ajpcell.00041.2018

PMCID:: PMC6171038

Article

Select item 571039317.

Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery

Cynthia Yu-Wai-Man, Aristides D. Tagalakis, Jinhong Meng, Yann Bouremel, Richard M. H. Lee, Alex Virasami, Stephen L. Hart, Peng T. Khaw

JAMA Ophthalmol. 2017 Nov; 135(11): 1147–1155. Prepublished online 2017 Sep 21. Published online 2017 Nov 9. doi: 10.1001/jamaophthalmol.2017.3407

PMCID:: PMC5710393

Article

Select item 548607518.

Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice

Kimberly A. Waller, Ling X. Zhang, Gregory D. Jay

Int J Mol Sci. 2017 Jun; 18(6): 1252. Published online 2017 Jun 11. doi: 10.3390/ijms18061252

PMCID:: PMC5486075

Article PDF–3.8M

Select item 542302519.

The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay, Khaled A. Elsaid

Arthritis Res Ther. 2017; 19: 89. Published online 2017 May 8. doi: 10.1186/s13075-017-1301-5

PMCID:: PMC5423025

Article PDF–2.2M

Select item 475096320.

Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo

Yusuke Nakagawa, Takeshi Muneta, Koji Otabe, Nobutake Ozeki, Mitsuru Mizuno, Mio Udo, Ryusuke Saito, Katsuaki Yanagisawa, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya

PLoS One. 2016; 11(2): e0148777. Published online 2016 Feb 11. doi: 10.1371/journal.pone.0148777