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Select item 115189951.

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

Clarissa N. Pacyna, Madhanagopal Anandapadamanaban, Kevin W. Loudon, Iain M. Hay, Olga Perisic, Ruoyan Li, Matthew Byrne, Laura Allen, Kirsty Roberts, Yvette Hooks, Anne Y. Warren, Grant D. Stewart, Menna R. Clatworthy, Sarah A. Teichmann, Sam Behjati, Peter J. Campbell, Roger L. Williams, Thomas J. Mitchell

Oncogene. 2024; 43(44): 3268–3276. Published online 2024 Sep 13. doi: 10.1038/s41388-024-03137-7

PMCID:: PMC11518995

Article PDF–1.3M

Select item 114674062.

mTOR signalling controls the formation of smooth muscle cell-derived luminal myofibroblasts during vasculitis

Angus T Stock, Sarah Parsons, Jacinta A Hansen, Damian B D’Silva, Graham Starkey, Aly Fayed, Xin Yi Lim, Rohit D’Costa, Claire L Gordon, Ian P Wicks

EMBO Rep. 2024 Oct; 25(10): 4570–4593. Published online 2024 Sep 13. doi: 10.1038/s44319-024-00251-1

PMCID:: PMC11467406

Article PDF–10M

Select item 113645743.

Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway

Haochi Yang, Binghuo Wu, Qi yang, Tian Tan, Dan Shang, Jie Chen, Chenhui Cao, Chuan Xu

J Nat Med. 2024; 78(4): 887–900. Published online 2024 Jun 7. doi: 10.1007/s11418-024-01821-2

PMCID:: PMC11364574

Article PDF–8.4M

Select item 113610554.

mTOR gene variant rs2295080 might be a risk factor for atherosclerosis in Iranian women with type 2 diabetes mellitus

Afsaneh Zare, Shahdad khosropanah, Gholamreza Daryabor, Mehrnoosh Doroudchi

BMC Endocr Disord. 2024; 24: 162. Published online 2024 Aug 29. doi: 10.1186/s12902-024-01703-4

PMCID:: PMC11361055

Article PDF–821K

Select item 112456865.

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation

Joël E. J. Beaumont, Lydie M. O. Barbeau, Jinzhe Ju, Kim G. Savelkouls, Freek G. Bouwman, Marijke I. Zonneveld, Annelies Bronckaers, Kim R. Kampen, Tom G. H. Keulers, Kasper M. A. Rouschop

J Extracell Vesicles. 2024 Jul; 13(7): e12449. Published online 2024 Jul 13. doi: 10.1002/jev2.12449

PMCID:: PMC11245686

Article PDF–5.5M

Select item 111146916.

Regulatory T cells, mTOR kinase, and metabolic activity

Claudio Procaccini, Giuseppe Matarese

Cell Mol Life Sci. 2012 Dec; 69(23): 3975–3987. Published online 2012 Jul 4. doi: 10.1007/s00018-012-1058-6

PMCID:: PMC11114691

Article PDF–328K

Select item 109316427.

mTOR Signaling: Recent Progress

Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou

Int J Mol Sci. 2024 Mar; 25(5): 2587. Published online 2024 Feb 23. doi: 10.3390/ijms25052587

PMCID:: PMC10931642

Article PDF–177K

Select item 108961818.

Malignant Brain Aging: The Formidable Link Between Dysregulated Signaling Through Mechanistic Target of Rapamycin Pathways and Alzheimer’s Disease (Type 3 Diabetes)

Suzanne M. de la Monte

J Alzheimers Dis. Author manuscript; available in PMC 2024 Feb 26.

Published in final edited form as: J Alzheimers Dis. 2023; 95(4): 1301–1337. doi: 10.3233/JAD-230555

PMCID:: PMC10896181

Article PDF–522K

Select item 108780359.

Human cytomegalovirus modulates mTORC1 to redirect mRNA translation within quiescently infected monocytes

Michael J. Miller, Dilruba Akter, Jamil Mahmud, Gary C. Chan

J Virol. 2024 Feb; 98(2): e01888-23. Published online 2024 Jan 30. doi: 10.1128/jvi.01888-23

PMCID:: PMC10878035

Article PDF–3.6M

Select item 1084380510.

Mechanistic target of rapamycin in regulating macrophage function in inflammatory cardiovascular diseases

MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao

J Mol Cell Cardiol. Author manuscript; available in PMC 2024 Feb 5.

Published in final edited form as: J Mol Cell Cardiol. 2024 Jan; 186: 111–124. Published online 2023 Nov 30. doi: 10.1016/j.yjmcc.2023.10.011

PMCID:: PMC10843805

Article PDF–964K

Select item 1082510911.

mTOR Plays an Important Role in the Stemness of Human Fetal Cartilage Progenitor Cells (hFCPCs)

Him-Cha Shin, Jiyoung Kim, So Ra Park, Byung Hyune Choi

Tissue Eng Regen Med. 2024 Feb; 21(2): 309–318. Published online 2023 Oct 9. doi: 10.1007/s13770-023-00598-x

PMCID:: PMC10825109

Article PDF–943K

Select item 1069518012.

mTOR pathway candidate genes and obesity interaction on breast cancer risk in Black women from the Women’s Circle of Health Study

Mmadili N. Ilozumba, Lusine Yaghjyan, Susmita Datta, Jinying Zhao, Chi-Chen Hong, Kathryn L. Lunetta, Gary Zirpoli, Elisa V. Bandera, Julie R. Palmer, Song Yao, Christine B. Ambrosone, Ting-Yuan David Cheng

Cancer Causes Control. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Cancer Causes Control. 2023 May; 34(5): 431–447. Published online 2023 Feb 15. doi: 10.1007/s10552-022-01657-9

PMCID:: PMC10695180

Article PDF–737K

Select item 1063394713.

Deep histopathology genotype–phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb

Jonas Honke, Lucas Hoffmann, Roland Coras, Katja Kobow, Costin Leu, Tom Pieper, Till Hartlieb, Christian G. Bien, Friedrich Woermann, Thomas Cloppenborg, Thilo Kalbhenn, Ahmed Gaballa, Hajo Hamer, Sebastian Brandner, Karl Rössler, Arnd Dörfler, Stefan Rampp, Johannes R. Lemke, Sara Baldassari, Stéphanie Baulac, Dennis Lal, Peter Nürnberg, Ingmar Blümcke

Acta Neuropathol Commun. 2023; 11: 179. Published online 2023 Nov 9. doi: 10.1186/s40478-023-01675-x

PMCID:: PMC10633947

Article PDF–1.9M

Select item 1060634114.

Signaling Pathways mTOR and ERK as Therapeutic Targets in Sinonasal Intestinal-Type Adenocarcinoma

Helena Codina-Martínez, Sara Lucila Lorenzo-Guerra, Virginia N. Cabal, Rocío García-Marín, Laura Suárez-Fernández, Blanca Vivanco, Paula Sánchez-Fernández, Fernando López, José Luis Llorente, Mario A. Hermsen

Int J Mol Sci. 2023 Oct; 24(20): 15110. Published online 2023 Oct 12. doi: 10.3390/ijms242015110

PMCID:: PMC10606341

Article PDF–1.5M

Select item 1045412115.

Signaling Pathways Leading to mTOR Activation Downstream Cytokine Receptors in Lymphocytes in Health and Disease

Lucie Fallone, Thierry Walzer, Antoine Marçais

Int J Mol Sci. 2023 Aug; 24(16): 12736. Published online 2023 Aug 13. doi: 10.3390/ijms241612736

PMCID:: PMC10454121

Article PDF–2.0M

Select item 1045300816.

Metabolic Disruption Induced by mTOR Signaling Pathway Inhibition in Regulatory T-Cell Expansion for Clinical Application

Roberto Gedaly, Gabriel Orozco, Alexandre P. Ancheta, Mackenzie Donoho, Siddharth N. Desai, Fanny Chapelin, Aman Khurana, Lillie J. Lewis, Cuiping Zhang, Francesc Marti

Cells. 2023 Aug; 12(16): 2066. Published online 2023 Aug 15. doi: 10.3390/cells12162066

PMCID:: PMC10453008

Article PDF–3.2M

Select item 1038053217.

mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy

Yuan Gao, Tian Tian

Int J Mol Sci. 2023 Jul; 24(14): 11811. Published online 2023 Jul 22. doi: 10.3390/ijms241411811

PMCID:: PMC10380532

Article PDF–1.6M

Select item 1027554218.

Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy

Wei Zhao, Cong Xie, Xu Zhang, Ju Liu, Jinzhi Liu, Zhangyong Xia

Brain Behav. 2023 Jun; 13(6): e2995. Published online 2023 May 23. doi: 10.1002/brb3.2995

PMCID:: PMC10275542

Article PDF–469K

Select item 1026275419.

Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage

Jingyue Jia, Fulong Wang, Zambarlal Bhujabal, Ryan Peters, Michal Mudd, Thabata Duque, Lee Allers, Ruheena Javed, Michelle Salemi, Christian Behrends, Brett Phinney, Terje Johansen, Vojo Deretic

Autophagy. 2023; 19(6): 1893–1895. Published online 2022 Nov 29. doi: 10.1080/15548627.2022.2148900

PMCID:: PMC10262754

Article PDF–458K

Select item 1024019820.

Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures

Daisuke Nanba, Jun‐Ichi Sakabe, Johannes Mosig, Michel Brouard, Fujio Toki, Mariko Shimokawa, Mako Kamiya, Thomas Braschler, Fahd Azzabi, Stéphanie Droz‐Georget Lathion, Kai Johnsson, Keya Roy, Christoph D Schmid, Jean‐Baptiste Bureau, Ariane Rochat, Yann Barrandon

EMBO Rep. 2023 Jun; 24(6): e55439. Published online 2023 May 4. doi: 10.15252/embr.202255439

PMCID:: PMC10240198

Article PDF–5.1M

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