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Select item 111103411.

UCHL5 promotes hepatocellular carcinoma progression by promoting glycolysis through activating Wnt/β-catenin pathway

Baishun Wan, Ming Cheng, Tao He, Ling Zhang

BMC Cancer. 2024; 24: 618. Published online 2024 May 21. doi: 10.1186/s12885-023-11317-z

PMCID:: PMC11110341

Article PDF–2.7M

Select item 77184372.

Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation

Kirandeep K. Deol, Sean O. Crowe, Jiale Du, Heather A. Bisbee, Robert G. Guenette, Eric R. Strieter

Mol Cell. Author manuscript; available in PMC 2021 Dec 3.

Published in final edited form as: Mol Cell. 2020 Dec 3; 80(5): 796–809.e9. Published online 2020 Nov 5. doi: 10.1016/j.molcel.2020.10.017

PMCID:: PMC7718437

Article PDF–2.9M

Select item 58250373.

Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis

Leena Arpalahti, Alli Laitinen, Jaana Hagström, Harri Mustonen, Arto Kokkola, Camilla Böckelman, Caj Haglund, Carina I. Holmberg

PLoS One. 2018; 13(2): e0193125. Published online 2018 Feb 23. doi: 10.1371/journal.pone.0193125

Correction in:: PLoS One. 2018; 13(5): e0197013.

PMCID:: PMC5825037

Article PDF–4.7M

Select item 33361034.

Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

Tushar K. Maiti, Michelle Permaul, David A. Boudreaux, Christina Mahanic, Sarah Mauney, Chittaranjan Das

FEBS J. Author manuscript; available in PMC 2012 Dec 1.

Published in final edited form as: FEBS J. 2011 Dec; 278(24): 4917–4926. Published online 2011 Nov 11. doi: 10.1111/j.1742-4658.2011.08393.x

PMCID:: PMC3336103

Article PDF–2.8M

Select item 32516365.

Structural characterization of human Uch37.

E. Sethe Burgie, Craig A. Bingman, Ameet B. Soni, George N. Phillips, Jr.

Proteins. Author manuscript; available in PMC 2013 Feb 2.

Published in final edited form as: Proteins. 2012 Feb; 80(2): 649–654. Published online 2011 Sep 26. doi: 10.1002/prot.23147

PMCID:: PMC3251636

Article PDF–772K

Select item 90333016.

A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation

Jiale Du, Sandor Babik, Yanfeng Li, Kirandeep K Deol, Stephen J Eyles, Jasna Fejzo, Marco Tonelli, Eric Strieter

eLife. 2022; 11: e76100. Published online 2022 Apr 22. doi: 10.7554/eLife.76100

PMCID:: PMC9033301

Article PDF–11M

Select item 89016347.

UCHL5 controls β-catenin destruction complex function through Axin1 regulation

Wonhee Han, Youngmu Koo, Leila Chaieb, Byeong-Rak Keum, Jin-Kwan Han

Sci Rep. 2022; 12: 3687. Published online 2022 Mar 7. doi: 10.1038/s41598-022-07642-1

PMCID:: PMC8901634

Article PDF–1.9M

Select item 68398548.

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Jayashree Chadchankar, Victoria Korboukh, Leslie C. Conway, Heike J. Wobst, Chandler A. Walker, Peter Doig, Steve J. Jacobsen, Nicholas J. Brandon, Stephen J. Moss, Qi Wang

PLoS One. 2019; 14(11): e0225145. Published online 2019 Nov 8. doi: 10.1371/journal.pone.0225145

PMCID:: PMC6839854

Article PDF–3.4M

Select item 51480589.

Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells

A Paulus, S Akhtar, T R Caulfield, K Samuel, H Yousaf, Y Bashir, S M Paulus, D Tran, R Hudec, D Cogen, J Jiang, B Edenfield, A Novak, S M Ansell, T Witzig, P Martin, M Coleman, V Roy, S Ailawadhi, K Chitta, S Linder, A Chanan-Khan

Blood Cancer J. 2016 Nov; 6(11): e492. Published online 2016 Nov 4. doi: 10.1038/bcj.2016.93

PMCID:: PMC5148058

Article PDF–4.9M

Select item 486144510.

The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression

Leah Randles, Ravi K. Anchoori, Richard B. S. Roden, Kylie J. Walters

J Biol Chem. 2016 Apr 15; 291(16): 8773–8783. Published online 2016 Feb 23. doi: 10.1074/jbc.M115.694588

PMCID:: PMC4861445

Article PDF–1.9M

Select item 413092411.

Mechanism of the Rpn13-induced activation of Uch37

Lianying Jiao, Songying Ouyang, Neil Shaw, Gaojie Song, Yingang Feng, Fengfeng Niu, Weicheng Qiu, Hongtao Zhu, Li-Wei Hung, Xiaobing Zuo, V. Eleonora Shtykova, Ping Zhu, Yu-Hui Dong, Ruxiang Xu, Zhi-Jie Liu

Protein Cell. 2014 Aug; 5(8): 616–630. Published online 2014 Apr 22. doi: 10.1007/s13238-014-0046-z

PMCID:: PMC4130924

Article PDF–2.2M

Select item 390775612.

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Ze Tian, Padraig D’Arcy, Xin Wang, Arghya Ray, Yu-Tzu Tai, Yiguo Hu, Ruben D. Carrasco, Paul Richardson, Stig Linder, Dharminder Chauhan, Kenneth C. Anderson

Blood. 2014 Jan 30; 123(5): 706–716. Prepublished online 2013 Dec 6. doi: 10.1182/blood-2013-05-500033

PMCID:: PMC3907756

Article

Select item 1053068613.

The TGF-β/UCHL5/Smad2 Axis Contributes to the Pathogenesis of Placenta Accreta

Kei Hashimoto, Yuko Miyagawa, Saya Watanabe, Kazuki Takasaki, Miki Nishizawa, Keita Yatsuki, Yuko Takahashi, Hideo Kamata, Chikara Kihira, Haruko Hiraike, Yukifumi Sasamori, Koichiro Kido, Eiji Ryo, Kazunori Nagasaka

Int J Mol Sci. 2023 Sep; 24(18): 13706. Published online 2023 Sep 5. doi: 10.3390/ijms241813706

PMCID:: PMC10530686

Article PDF–3.3M

Select item 718370514.

LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5

Zheng Zhang, Xiaoxuan Hu, Jia Kuang, Jinmao Liao, Qi Yuan

Cell Mol Biol Lett. 2020; 25: 29. Published online 2020 Apr 25. doi: 10.1186/s11658-020-00221-0

PMCID:: PMC7183705

Article PDF–3.5M

Select item 530980615.

Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling

Wonhee Han, Hyeyoon Lee, Jin-Kwan Han

Sci Rep. 2017; 7: 42590. Published online 2017 Feb 15. doi: 10.1038/srep42590

PMCID:: PMC5309806

Article PDF–1.5M

Select item 418356216.

Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity

Ryotaro Nishi, Paul Wijnhoven, Carlos le Sage, Jorrit Tjeertes, Yaron Galanty, Josep V. Forment, Michael J. Clague, Sylvie Urbé, Stephen P Jackson

Nat Cell Biol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Nat Cell Biol. 2014 Oct; 16(10): 1016–8. Published online 2014 Sep 7. doi: 10.1038/ncb3028

PMCID:: PMC4183562

Article PDF–2.7M

Select item 288772217.

Structure of Proteasome Ubiquitin Receptor hRpn13 and its Activation by the Scaffolding Protein hRpn2

Xiang Chen, Byung-Hoon Lee, Daniel Finley, Kylie J. Walters

Mol Cell. Author manuscript; available in PMC 2011 May 14.

Published in final edited form as: Mol Cell. 2010 May 14; 38(3): 404–415. doi: 10.1016/j.molcel.2010.04.019

PMCID:: PMC2887722

Article PDF–3.4M

Select item 731248918.

Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration

Amit Sharma, Hongde Liu, Fabian Tobar-Tosse, Tikam Chand Dakal, Michael Ludwig, Frank G. Holz, Karin U. Loeffler, Ullrich Wüllner, Martina C. Herwig-Carl

Int J Mol Sci. 2020 Jun; 21(11): 3910. Published online 2020 May 30. doi: 10.3390/ijms21113910