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Items: 1 to 20 of 22

1.
A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
Brandon M. Huffman, Hanrong Feng, Kalindi Parmar, Junning Wang, Kevin S. Kapner, Bose Kochupurakkal, David B. Martignetti, Golbahar Sadatrezaei, Thomas A. Abrams, Leah H. Biller, Marios Giannakis, Kimmie Ng, Anuj K. Patel, Kimberly J. Perez, Harshabad Singh, Douglas A. Rubinson, Benjamin L. Schlechter, Elizabeth Andrews, Alison M. Hannigan, Stanley Dunwell, Zoe Getchell, Srivatsan Raghavan, Brian M. Wolpin, Caroline Fortier, Alan D. D’Andrea, Andrew J. Aguirre, Geoffrey I. Shapiro, James M. Cleary
Clin Cancer Res. Author manuscript; available in PMC 2024 Jun 15.
Published in final edited form as: Clin Cancer Res. 2023 Dec 15; 29(24): 5047–5056. doi: 10.1158/1078-0432.CCR-23-2005
PMCID:
PMC10842136
ArticlePDF–1.0M
2.
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis
Shu Zhang, Wen Fang, Siqi Zhou, Dongming Zhu, Ruidong Chen, Xin Gao, Zhuojin Li, Yao Fu, Yixuan Zhang, Fa Yang, Jing Zhao, Hao Wu, Pin Wang, Yonghua Shen, Shanshan Shen, Guifang Xu, Lei Wang, Chao Yan, Xiaoping Zou, Dijun Chen, Ying Lv
Nat Commun. 2023; 14: 5123. Published online 2023 Aug 23. doi: 10.1038/s41467-023-40727-7
PMCID:
PMC10447466
ArticlePDF–7.9M
3.
Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting
Chani Stossel, Maria Raitses-Gurevich, Dikla Atias, Tamar Beller, Yulia Glick Gorman, Sharon Halperin, Eyal Peer, Robert E. Denroche, Amy Zhang, Faiyaz Notta, Julie M. Wilson, Grainne M. O'Kane, Elina Haimov Talmoud, Nora Amison, Michael Schvimer, Seth J. Salpeter, Vered Bar, Adi Zundelevich, Itay Tirosh, Rotem Tal, Gal Dinstag, Yaron Kinar, Yonatan Eliezer, Uri Ben-David, Nancy S. Gavert, Ravid Straussman, Steven J. Gallinger, Raanan Berger, Talia Golan
Cancer Discov. 2023 Aug 4; 13(8): 1826–1843. Published online 2023 Jul 14. doi: 10.1158/2159-8290.CD-22-0412
PMCID:
PMC10401074
ArticlePDF–16M
4.
Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome immunotherapy resistance in pancreatic cancer
Jashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Siddharth Mehra, Vanessa Garrido, Purushottam Lamichhane, Samara Singh, Zhiqun Zhou, Austin R. Dosch, Fanuel Messaggio, Yuguang Ban, Oliver Umland, Peter J. Hosein, Nagaraj S. Nagathihalli, Nipun B. Merchant
Gastroenterology. Author manuscript; available in PMC 2023 Dec 1.
Published in final edited form as: Gastroenterology. 2022 Dec; 163(6): 1593–1612. Published online 2022 Aug 7. doi: 10.1053/j.gastro.2022.07.076
PMCID:
PMC10257389
ArticlePDF–3.8M
5.
Circulating Tumor and Invasive Cell Expression Profiling Predicts Effective Therapy in Pancreatic Cancer
Kenneth H. Yu, Jennifer Park, Avni Mittal, Ghassan K. Abou-Alfa, Imane El Dika, Andrew S. Epstein, David H. Ilson, David P. Kelsen, Geoffrey Y. Ku, Jia Li, Wungki Park, Anna M. Varghese, Joanne F-L Chou, Marinela Capanu, Brandon Cooper, Andrew Bartlett, Devan McCarthy, Vineet Sangar, Brian McCarthy, Eileen M. O’Reilly
Cancer. Author manuscript; available in PMC 2023 Aug 1.
Published in final edited form as: Cancer. 2022 Aug 1; 128(15): 2958–2966. Published online 2022 Jun 1. doi: 10.1002/cncr.34269
PMCID:
PMC10131181
ArticlePDF–1.0M
6.
Maintenance therapy of low-dose nivolumab, S-1, and leucovorin in metastatic pancreatic adenocarcinoma with a germline mutation of MSH6: A case report
Shang-Hsuan Peng, Bang-Bin Chen, Ting-Chun Kuo, Jen-Chieh Lee, Shih-Hung Yang
Front Immunol. 2022; 13: 1077840. Published online 2022 Dec 13. doi: 10.3389/fimmu.2022.1077840
PMCID:
PMC9792834
ArticlePDF–1.6M
7.
Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL
Russell Moser, James Annis, Olga Nikolova, Clifford J Whatcott, Kay E Gurley, Eduardo Mendez, Kim Moran-Jones, Craig Dorrell, Rosalie C Sears, Calvin J Kuo, Haiyong Han, Andrew V Biankin, Carla Grandori, Daniel D Von Hoff, Christopher J Kemp
Cancer Res. Author manuscript; available in PMC 2023 Mar 16.
Published in final edited form as: Cancer Res. 2022 Jul 12 : can.21.4222. Published online 2022 Jul 12. doi: 10.1158/0008-5472.CAN-21-4222
PMCID:
PMC9481717
ArticlePDF–2.1M
8.
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors
Shuxi Qiao, Siang-Boon Koh, Varunika Vivekanandan, Devika Salunke, Krushna Chandra Patra, Elma Zaganjor, Kenneth Ross, Yusuke Mizukami, Sarah Jeanfavre, Athena Chen, Mari Mino-Kenudson, Sridhar Ramaswamy, Clary Clish, Marcia Haigis, Nabeel Bardeesy, Leif W. Ellisen
Genes Dev. 2020 Jun 1; 34(11-12): 751–766. doi: 10.1101/gad.335166.119
PMCID:
PMC7263146
ArticlePDF–6.7M
9.
Pancreatic tropism of metastatic renal cell carcinoma
Nirmish Singla, Zhiqun Xie, Ze Zhang, Ming Gao, Qurratulain Yousuf, Oreoluwa Onabolu, Tiffani McKenzie, Vanina Toffessi Tcheuyap, Yuanqing Ma, Jacob Choi, Renee McKay, Alana Christie, Oscar Reig Torras, Isaac A. Bowman, Vitaly Margulis, Ivan Pedrosa, Christopher Przybycin, Tao Wang, Payal Kapur, Brian Rini, James Brugarolas
JCI Insight. 2020 Apr 9; 5(7): e134564. Published online 2020 Apr 9. doi: 10.1172/jci.insight.134564
PMCID:
PMC7205259
ArticlePDF–46M
10.
Tumor cell–intrinsic USP22 suppresses antitumor immunity in pancreatic cancer
Jinyang Li, Salina Yuan, Robert J Norgard, Fangxue Yan, Taiji Yamazoe, Andrés Blanco, Ben Z. Stanger
Cancer Immunol Res. Author manuscript; available in PMC 2020 Sep 1.
Published in final edited form as: Cancer Immunol Res. 2020 Mar; 8(3): 282–291. Published online 2019 Dec 23. doi: 10.1158/2326-6066.CIR-19-0661
PMCID:
PMC7173406
ArticlePDF–2.2M
11.
Implementing a comprehensive translational oncology platform: from molecular testing to actionability
Zahi I. Mitri, Swapnil Parmar, Brett Johnson, Annette Kolodzie, Jamie M. Keck, Max Morris, Alexander R. Guimaraes, Brooke R. Beckett, Uma Borate, Charles D. Lopez, Kathleen A. Kemmer, Joshi J. Alumkal, Tomasz M. Beer, Christopher L. Corless, Gordon B. Mills, Joe W. Gray, Raymond C. Bergan
J Transl Med. 2018; 16: 358. Published online 2018 Dec 14. doi: 10.1186/s12967-018-1733-y
PMCID:
PMC6295039
ArticlePDF–1.3M
12.
Personalized treatment based on mini patient-derived xenografts and WES/RNA sequencing in a patient with metastatic duodenal adenocarcinoma
Peng Zhao, Hui Chen, Danyi Wen, Shuo Mou, Feifei Zhang, Shusen Zheng
Cancer Commun (Lond) 2018; 38: 54. Published online 2018 Aug 23. doi: 10.1186/s40880-018-0323-y
PMCID:
PMC6108145
ArticlePDF–1.5M
13.
Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial
Gregory L. Beatty, Mark H. O’Hara, Simon F. Lacey, Drew A. Torigian, Farzana Nazimuddin, Fang Chen, Irina M. Kulikovskaya, Michael C. Soulen, Maureen McGarvey, Anne Marie Nelson, Whitney L. Gladney, Bruce L. Levine, J. Joseph Melenhorst, Gabriela Plesa, Carl H. June
Gastroenterology. Author manuscript; available in PMC 2019 Jul 1.
Published in final edited form as: Gastroenterology. 2018 Jul; 155(1): 29–32. Published online 2018 Mar 20. doi: 10.1053/j.gastro.2018.03.029
PMCID:
PMC6035088
ArticlePDF–452K
14.
Tribody [(HER2)2xCD16] Is More Effective Than Trastuzumab in Enhancing γδ T Cell and Natural Killer Cell Cytotoxicity Against HER2-Expressing Cancer Cells
Hans H. Oberg, Christian Kellner, Daniel Gonnermann, Susanne Sebens, Dirk Bauerschlag, Martin Gramatzki, Dieter Kabelitz, Matthias Peipp, Daniela Wesch
Front Immunol. 2018; 9: 814. Published online 2018 Apr 19. doi: 10.3389/fimmu.2018.00814
PMCID:
PMC5916959
ArticlePDF–6.6M
15.
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors
Ahmad Al-Hader, Rami N Al-Rohil, Haiyong Han, Daniel Von Hoff
World J Gastroenterol. 2017 Dec 7; 23(45): 7945–7951. Published online 2017 Dec 7. doi: 10.3748/wjg.v23.i45.7945
PMCID:
PMC5725289
ArticlePDF–1.0M
16.
Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
Patricia M. LoRusso, Charles M. Rudin, Josina C. Reddy, Raoul Tibes, Glen J. Weiss, Mitesh J. Borad, Christine L. Hann, Julie R. Brahmer, Ilsung Chang, Walter C. Darbonne, Richard A. Graham, Kenn L. Zerivitz, Jennifer A. Low, Daniel D. Von Hoff
Clin Cancer Res. Author manuscript; available in PMC 2017 Jan 19.
Published in final edited form as: Clin Cancer Res. 2011 Apr 15; 17(8): 2502–2511. Published online 2011 Feb 7. doi: 10.1158/1078-0432.CCR-10-2745
PMCID:
PMC5244484
ArticlePDF–405K
17.
Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies
Elena Gabriela Chiorean, Andrew L Coveler
Drug Des Devel Ther. 2015; 9: 3529–3545. Published online 2015 Jul 7. doi: 10.2147/DDDT.S60328
PMCID:
PMC4500614
ArticlePDF–367K
18.
A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas
Steven Attia, Jill Kolesar, Michelle R. Mahoney, Henry C. Pitot, Daniel Laheru, James Heun, Wei Huang, Jens Eickhoff, Charles Erlichman, Kyle D. Holen
Invest New Drugs. Author manuscript; available in PMC 2015 Jun 9.
Published in final edited form as: Invest New Drugs. 2008 Aug; 26(4): 369–379. Published online 2008 Feb 16. doi: 10.1007/s10637-008-9123-6
PMCID:
PMC4461052
ArticlePDF–535K
19.
Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas
Irene Ischenko, Oleksi Petrenko, Michael J. Hayman
Proc Natl Acad Sci U S A. 2014 Mar 4; 111(9): 3466–3471. Published online 2014 Feb 18. doi: 10.1073/pnas.1319911111
PMCID:
PMC3948305
ArticlePDF–1.1M
20.
Beyond first-line chemotherapy for advanced pancreatic cancer: An expanding array of therapeutic options?
Evan J Walker, Andrew H Ko
World J Gastroenterol. 2014 Mar 7; 20(9): 2224–2236. Published online 2014 Mar 7. doi: 10.3748/wjg.v20.i9.2224
PMCID:
PMC3942828
ArticlePDF–932K

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