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Select item 67266941.

A novel pan‐cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic

Wei Liu, Jie Li, Ping Zhang, Qiaoyun Hou, Shi Feng, Lisheng Liu, Dawei Cui, Hubing Shi, Yan Fu, Yongzhang Luo

Cancer Sci. 2019 Sep; 110(9): 2941–2959. Published online 2019 Aug 9. doi: 10.1111/cas.14143

PMCID:: PMC6726694

Article PDF–2.5M

Select item 65619352.

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

Wanping Xu, Kristin Beebe, Juan D. Chavez, Marta Boysen, YinYing Lu, Abbey D. Zuehlke, Dimitra Keramisanou, Jane B. Trepel, Christosomos Prodromou, Matthias P. Mayer, James E. Bruce, Ioannis Gelis, Len Neckers

Nat Commun. 2019; 10: 2574. Published online 2019 Jun 12. doi: 10.1038/s41467-019-10463-y

PMCID:: PMC6561935

Article PDF–3.2M

Select item 65524293.

Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor

Manisha Dagar, Julie Pratibha Singh, Gunjan Dagar, Rakesh K. Tyagi, Gargi Bagchi

J Biol Chem. 2019 May 31; 294(22): 8699–8710. Published online 2019 Apr 16. doi: 10.1074/jbc.RA119.007420

PMCID:: PMC6552429

Article PDF–2.1M

Select item 3604394.

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84).

R Shaknovich, G Shue, D S Kohtz

Mol Cell Biol. 1992 Nov; 12(11): 5059–5068. doi: 10.1128/mcb.12.11.5059

PMCID:: PMC360439

Article PDF–2.5M

Select item 65438705.

Machine Learning Analysis of τRAMD Trajectories to Decipher Molecular Determinants of Drug-Target Residence Times

Daria B. Kokh, Tom Kaufmann, Bastian Kister, Rebecca C. Wade

Front Mol Biosci. 2019; 6: 36. Published online 2019 May 24. doi: 10.3389/fmolb.2019.00036

PMCID:: PMC6543870

Article PDF–7.2M

Select item 64878896.

Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains

Juan Guevara, Jr., Jamie Romo, Jr., Ernesto Hernandez, Natalia Valentinova Guevara

Protein J. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Protein J. 2018 Dec; 37(6): 548–571. doi: 10.1007/s10930-018-9792-8

PMCID:: PMC6487889

Article PDF–2.9M

Select item 59736267.

A secreted Heat shock protein 90 of Trichomonas vaginalis

Meetali Singh, Divya Beri, Rishi Kumar Nageshan, Leena Chavaan, Darshak Gadara, Mukta Poojary, Suraj Subramaniam, Utpal Tatu

PLoS Negl Trop Dis. 2018 May; 12(5): e0006493. Published online 2018 May 16. doi: 10.1371/journal.pntd.0006493

PMCID:: PMC5973626

Article PDF–7.1M

Select item 59401468.

The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans

James L. Lissemore, Elyse Connors, Ying Liu, Li Qiao, Bing Yang, Mark L. Edgley, Stephane Flibotte, Jon Taylor, Vinci Au, Donald G. Moerman, Eleanor M. Maine

G3 (Bethesda) 2018 May; 8(5): 1535–1544. Published online 2018 Mar 5. doi: 10.1534/g3.118.300551

PMCID:: PMC5940146

Article PDF–1.3M

Select item 57416249.

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

M. Amaral, D. B. Kokh, J. Bomke, A. Wegener, H. P. Buchstaller, H. M. Eggenweiler, P. Matias, C. Sirrenberg, R. C. Wade, M. Frech

Nat Commun. 2017; 8: 2276. Published online 2017 Dec 22. doi: 10.1038/s41467-017-02258-w

PMCID:: PMC5741624

Article PDF–2.5M

Select item 535235210.

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells

Arefeh Rouhi, Christina Miller, Sarah Grasedieck, Stefanie Reinhart, Britta Stolze, Hartmut Döhner, Florian Kuchenbauer, Lars Bullinger, Stefan Fröhling, Claudia Scholl

Oncotarget. 2017 Jan 31; 8(5): 7678–7690. Published online 2016 Dec 9. doi: 10.18632/oncotarget.13841

PMCID:: PMC5352352

Article PDF–9.1M

Select item 507268711.

Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis

Fumika Mi-ichi, Hiroki Yoshida, Shinjiro Hamano

PLoS Pathog. 2016 Oct; 12(10): e1005845. Published online 2016 Oct 20. doi: 10.1371/journal.ppat.1005845

PMCID:: PMC5072687

Article PDF–1.3M

Select item 496698212.

The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas

Jaimee Reck, Alexandria M. Schauer, Kristyn VanderWaal Mills, Raqual Bower, Douglas Tritschler, Catherine A. Perrone, Mary E. Porter

Mol Biol Cell. 2016 Aug 1; 27(15): 2404–2422. doi: 10.1091/mbc.E16-03-0191

PMCID:: PMC4966982

Article PDF–1.5M

Select item 493245213.

Mutations Y493G and K546D in human HSP90 disrupt binding of celastrol and reduce interaction with Cdc37

Bin Peng, Yi‐Jun Gu, Ying Wang, Fan‐Fan Cao, Xue Zhang, Deng‐Hai Zhang, Jian Hou

FEBS Open Bio. 2016 Jul; 6(7): 729–734. Published online 2016 May 25. doi: 10.1002/2211-5463.12081

PMCID:: PMC4932452

Article PDF–557K

Select item 481842114.

Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells

Yang Lu, Jingchao Wang, Chen Dapeng, Di Wu, Guangyan Cai, Xiangmei Chen

BMC Nephrol. 2016; 17: 39. Published online 2016 Apr 1. doi: 10.1186/s12882-016-0249-z

PMCID:: PMC4818421

Article PDF–2.7M

Select item 451937015.

Regulation and function of the human HSP90AA1 gene

Abbey D. Zuehlke, Kristin Beebe, Len Neckers, Thomas Prince

Gene. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Gene. 2015 Oct 1; 570(1): 8–16. Published online 2015 Jun 10. doi: 10.1016/j.gene.2015.06.018

PMCID:: PMC4519370

Article PDF–2.0M

Select item 442313016.

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

Katarína Vaškovičová, Emilia Szabadosová, Vladimír Čermák, Aneta Gandalovičová, Lenka Kasalová, Daniel Rösel, Jan Brábek

BMC Cancer. 2015; 15: 326. Published online 2015 Apr 29. doi: 10.1186/s12885-015-1347-1

PMCID:: PMC4423130

Article PDF–1.0M

Select item 409744617.

Epitope Mapping of the HSP83.1 Protein of Leishmania braziliensis Discloses Novel Targets for Immunodiagnosis of Tegumentary and Visceral Clinical Forms of Leishmaniasis

Daniel Menezes-Souza, Tiago Antônio de Oliveira Mendes, Matheus de Souza Gomes, João Luís Reis-Cunha, Ronaldo Alves Pinto Nagem, Cláudia Martins Carneiro, Eduardo Antônio Ferraz Coelho, Lúcia Maria da Cunha Galvão, Ricardo Toshio Fujiwara, Daniella Castanheira Bartholomeu

Clin Vaccine Immunol. 2014 Jul; 21(7): 949–959. doi: 10.1128/CVI.00151-14