All-trans retinoic acid effect on HL60 myeloid cells overexpressing ecotropic virus integration site 1
Summary:
Analysis of EVI1-overexpressing HL60 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citations:
Steinmetz B, Hackl H, Slabáková E, Schwarzinger I et al. The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid. Cell Cycle 2014;13(18):2931-43. PMID: 25486480
