|
| Status |
Public on Oct 31, 2016 |
| Title |
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In this study we investigated changes in gene expression induced by 2cPE (a non-selective isopeptidase inhibitor) in leukemia cells isolated from 10 different patients suffering of B-cell chronic lymphocytic leukemia. We compared 2cPE induced changes in mRNA levels with those induced by bortezomib, another well characterized proteasome inhibitor. Both inhibitors trigger apoptosis in leukemia cells.
|
| |
|
| Overall design |
Gene expression profiles of B-CLL cells coming from several patients treated with the UPS inhibitors bortezomib and 2cPE are compared to the profiles of untreated cells.
|
| |
|
| Contributor(s) |
Tomasella A, Picco R, Agorbissa A, Bianchi E, Manfredini R, Benedetti F, Valentina T, Frezzato F, Trentin L, Sememzato G, Delia D, Brancolini C |
| Citation(s) |
27259251 |
| |
| Submission date |
Oct 30, 2015 |
| Last update date |
Jan 30, 2017 |
| Contact name |
raffaella picco |
| E-mail(s) |
raf.picco@uniud.it
|
| Organization name |
university of Udine
|
| Department |
department of medical and biological sciences
|
| Lab |
bioinformatics
|
| Street address |
piazzale kolbe 4
|
| City |
udine |
| ZIP/Postal code |
33100 |
| Country |
Italy |
| |
|
| Platforms (1) |
| GPL20650 |
[HG-U219_Hs_ENTREZG_18] Affymetrix Human Genome U219 Array [CDF: Brainarray HGU219_Hs_ENTREZG_v18] |
|
| Samples (26)
|
|
| Relations |
| BioProject |
PRJNA300624 |
Less...
More...