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Hepatic granuloma

MedGen UID:
155428
•Concept ID:
C0745754
•
Disease or Syndrome
Synonyms: Hepatic Granuloma; hepatic granuloma; Liver Granuloma
SNOMED CT: Hepatic granuloma (714253009)
 
Monarch Initiative: MONDO:0006241

Definition

A granuloma located in the liver. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatic granuloma

Professional guidelines

PubMed

The role of microRNAs in the pathogenesis, grading and treatment of hepatic fibrosis in schistosomiasis.
Chen Q, Zhang J, Zheng T, Chen H, Nie H, Zheng B, Gong Q
Parasit Vectors 2019 Dec 30;12(1):611. doi: 10.1186/s13071-019-3866-0. PMID: 31888743Free PMC Article

Recent clinical studies

Etiology

Sodium butyrate ameliorates Schistosoma japonicum-induced liver fibrosis by inhibiting HMGB1 expression.
Chen H, Li G, Zhang J, Zheng T, Chen Q, Zhang Y, Yang F, Wang C, Nie H, Zheng B, Gong Q
Exp Parasitol 2021 Dec;231:108171. Epub 2021 Nov 2 doi: 10.1016/j.exppara.2021.108171. PMID: 34736899
Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case.
Yamamoto T, Miyazaki T, Kurashima Y, Ohata K, Okawa M, Tanaka S, Uenishi T, Miyaji K, Fukumoto N
Int Surg 2015 Jun;100(6):1011-7. doi: 10.9738/INTSURG-D-14-00126.1. PMID: 26414822Free PMC Article
Solitary hepatic granuloma preoperatively diagnosed as intrahepatic cholangiocellular carcinoma: report of a case.
Fukushima D, Iwane T, Sato K, Kawagishi N, Sekiguchi S, Ishida K, Satomi S
Surg Today 2012 Dec;42(12):1229-33. Epub 2012 Jun 8 doi: 10.1007/s00595-012-0216-7. PMID: 22678661
Hepatobiliary tuberculosis in western India.
Amarapurkar DN, Patel ND, Amarapurkar AD
Indian J Pathol Microbiol 2008 Apr-Jun;51(2):175-81. doi: 10.4103/0377-4929.41644. PMID: 18603675
Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas.
Mert A, Tabak F, Ozaras R, Ozturk R, Aki H, Aktuglu Y
Intern Med 2004 May;43(5):436-9. doi: 10.2169/internalmedicine.43.436. PMID: 15206561

Diagnosis

Q fever presenting with hepatic and splenic lesions in a kidney transplant recipient.
Sarrell BA, Laurenzano J, Freitas J, Concepcion BP
Transpl Infect Dis 2021 Oct;23(5):e13699. Epub 2021 Aug 8 doi: 10.1111/tid.13699. PMID: 34324786
Hepatic granuloma mimicking an intrahepatic cholangiocarcinoma: An unusual presentation.
Blanco Terés L, Di Martino M, Rodríguez ÁH, Martín-Pérez E
Cir Esp (Engl Ed) 2021 May;99(5):383. Epub 2020 Jul 15 doi: 10.1016/j.ciresp.2020.06.006. PMID: 32682513
Enfermedad granulomatosa hepática.
Ortiz-Brizuela E, Azamar-Llamas D, Mora JD, Guerrero-Castillo JI, Martínez-Benítez B, Sifuentes-Osornio J
Gac Med Mex 2019;155(3):266-275. doi: 10.24875/GMM.18004327. PMID: 31219474
Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas.
Mert A, Tabak F, Ozaras R, Ozturk R, Aki H, Aktuglu Y
Intern Med 2004 May;43(5):436-9. doi: 10.2169/internalmedicine.43.436. PMID: 15206561
Pattern of chronic liver disease in the eastern province of Saudi Arabia. A hospital-based clinicopathological study.
al-Quorain A, Satti MB, al-Hamdan AR, al-Gindan Y, Ibrahim E, Khatib R, al-Freihi H
Trop Geogr Med 1994;46(6):358-60. PMID: 7892703

Therapy

Potential Gut Microbiota Features for Non-Invasive Detection of Schistosomiasis.
Lin D, Song Q, Liu J, Chen F, Zhang Y, Wu Z, Sun X, Wu X
Front Immunol 2022;13:941530. Epub 2022 Jul 14 doi: 10.3389/fimmu.2022.941530. PMID: 35911697Free PMC Article
Q fever presenting with hepatic and splenic lesions in a kidney transplant recipient.
Sarrell BA, Laurenzano J, Freitas J, Concepcion BP
Transpl Infect Dis 2021 Oct;23(5):e13699. Epub 2021 Aug 8 doi: 10.1111/tid.13699. PMID: 34324786
The role of microRNAs in the pathogenesis, grading and treatment of hepatic fibrosis in schistosomiasis.
Chen Q, Zhang J, Zheng T, Chen H, Nie H, Zheng B, Gong Q
Parasit Vectors 2019 Dec 30;12(1):611. doi: 10.1186/s13071-019-3866-0. PMID: 31888743Free PMC Article
Taurine drinking ameliorates hepatic granuloma and fibrosis in mice infected with Schistosoma japonicum.
Yu YR, Ni XQ, Huang J, Zhu YH, Qi YF
Int J Parasitol Drugs Drug Resist 2016 Apr;6(1):35-43. Epub 2016 Jan 14 doi: 10.1016/j.ijpddr.2016.01.003. PMID: 27054062Free PMC Article
Lessons from other diseases: granulomatous inflammation in leishmaniasis.
Kaye PM, Beattie L
Semin Immunopathol 2016 Mar;38(2):249-60. Epub 2015 Dec 17 doi: 10.1007/s00281-015-0548-7. PMID: 26678994Free PMC Article

Prognosis

Potential Gut Microbiota Features for Non-Invasive Detection of Schistosomiasis.
Lin D, Song Q, Liu J, Chen F, Zhang Y, Wu Z, Sun X, Wu X
Front Immunol 2022;13:941530. Epub 2022 Jul 14 doi: 10.3389/fimmu.2022.941530. PMID: 35911697Free PMC Article
Hepatic granuloma: decreasing trend in a high-incidence area.
Sanai FM, Ashraf S, Abdo AA, Satti MB, Batwa F, Al-Husseini H, Saleh AM, Bzeizi KI
Liver Int 2008 Dec;28(10):1402-7. doi: 10.1111/j.1478-3231.2008.01837.x. PMID: 18694402
Prevalence of hepatic granulomas in chronic hepatitis B.
Tahan V, Ozaras R, Lacevic N, Ozden E, Yemisen M, Ozdogan O, Mert A, Tabak F, Avsar E, Celikel CA, Ozbay G, Kalayci C, Senturk H, Tozun N
Dig Dis Sci 2004 Oct;49(10):1575-7. doi: 10.1023/b:ddas.0000043366.18578.15. PMID: 15573907
Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas.
Mert A, Tabak F, Ozaras R, Ozturk R, Aki H, Aktuglu Y
Intern Med 2004 May;43(5):436-9. doi: 10.2169/internalmedicine.43.436. PMID: 15206561
Drug-induced hepatitis with hepatic granuloma due to saridon.
Abe M, Kumagi T, Nakanishi S, Yamagami T, Michitaka K, Abe K, Okura I, Yamashita H, Horiike N, Onji M
J Gastroenterol 2002;37(12):1068-72. doi: 10.1007/s005350200180. PMID: 12522541

Clinical prediction guides

Potential Gut Microbiota Features for Non-Invasive Detection of Schistosomiasis.
Lin D, Song Q, Liu J, Chen F, Zhang Y, Wu Z, Sun X, Wu X
Front Immunol 2022;13:941530. Epub 2022 Jul 14 doi: 10.3389/fimmu.2022.941530. PMID: 35911697Free PMC Article
IL-33 Contributes to Schistosoma japonicum-induced Hepatic Pathology through Induction of M2 Macrophages.
Peng H, Zhang Q, Li X, Liu Z, Shen J, Sun R, Wei J, Zhao J, Wu X, Feng F, Zhong S, Sun X, Wu Z
Sci Rep 2016 Jul 21;6:29844. doi: 10.1038/srep29844. PMID: 27445267Free PMC Article
Spatial and temporal transcriptomics of Schistosoma japonicum-induced hepatic granuloma formation reveals novel roles for neutrophils.
Chuah C, Jones MK, Burke ML, Owen HC, Anthony BJ, McManus DP, Ramm GA, Gobert GN
J Leukoc Biol 2013 Aug;94(2):353-65. Epub 2013 May 24 doi: 10.1189/jlb.1212653. PMID: 23709687
Hepatic granulomas: a clinicopathologic analysis of 86 cases.
Turhan N, Kurt M, Ozderin YO, Kurt OK
Pathol Res Pract 2011 Jun 15;207(6):359-65. Epub 2011 Apr 30 doi: 10.1016/j.prp.2011.03.003. PMID: 21531083
The role of cytokines in the formation of the schistosome egg granuloma.
Boros DL
Immunobiology 1994 Oct;191(4-5):441-50. doi: 10.1016/S0171-2985(11)80450-X. PMID: 7713558

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