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Germ cell benign neoplasm

MedGen UID:
272358
Concept ID:
C1332505
Neoplastic Process
Synonyms: Benign germ cell neoplasm; Benign Germ Cell Neoplasm; Benign Germ Cell Tumor; Benign Neoplasm of Germ Cell; Benign Neoplasm of the Germ Cell; Benign Tumor of Germ Cell; Benign Tumor of the Germ Cell; germ cell benign neoplasm
SNOMED CT: Benign germ cell neoplasm (713588001)
 
Monarch Initiative: MONDO:0850144

Definition

A germ cell tumor without evidence of atypia and metastatic potential. [from NCI]

Professional guidelines

PubMed

Saleh M, Bhosale P, Menias CO, Ramalingam P, Jensen C, Iyer R, Ganeshan D
Abdom Radiol (NY) 2021 Jun;46(6):2293-2307. Epub 2021 Jan 4 doi: 10.1007/s00261-020-02873-0. PMID: 33394097
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article
Lee PA, Houk CP, Ahmed SF, Hughes IA; International Consensus Conference on Intersex organized by the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology
Pediatrics 2006 Aug;118(2):e488-500. doi: 10.1542/peds.2006-0738. PMID: 16882788

Recent clinical studies

Etiology

Kubota Y, Viny AD
Semin Hematol 2024 Feb;61(1):61-67. Epub 2024 Jan 14 doi: 10.1053/j.seminhematol.2024.01.007. PMID: 38311514Free PMC Article
Bedrosian I, Somerfield MR, Achatz MI, Boughey JC, Curigliano G, Friedman S, Kohlmann WK, Kurian AW, Laronga C, Lynce F, Norquist BS, Plichta JK, Rodriguez P, Shah PD, Tischkowitz M, Wood M, Yadav S, Yao K, Robson ME
J Clin Oncol 2024 Feb 10;42(5):584-604. Epub 2024 Jan 4 doi: 10.1200/JCO.23.02225. PMID: 38175972
Guindalini RSC, Viana DV, Kitajima JPFW, Rocha VM, López RVM, Zheng Y, Freitas É, Monteiro FPM, Valim A, Schlesinger D, Kok F, Olopade OI, Folgueira MAAK
Sci Rep 2022 Mar 9;12(1):4190. doi: 10.1038/s41598-022-07383-1. PMID: 35264596Free PMC Article
Schmitt ML
Clin J Oncol Nurs 2021 Dec 1;25(6):21-22. doi: 10.1188/21.CJON.S2.21-22. PMID: 34800117
Silver AJ, Bick AG, Savona MR
Nat Rev Genet 2021 Sep;22(9):603-617. Epub 2021 May 13 doi: 10.1038/s41576-021-00356-6. PMID: 33986496Free PMC Article

Diagnosis

Houlahan KE, Khan A, Greenwald NF, Vivas CS, West RB, Angelo M, Curtis C
Science 2024 May 31;384(6699):eadh8697. doi: 10.1126/science.adh8697. PMID: 38815010
Bedrosian I, Somerfield MR, Achatz MI, Boughey JC, Curigliano G, Friedman S, Kohlmann WK, Kurian AW, Laronga C, Lynce F, Norquist BS, Plichta JK, Rodriguez P, Shah PD, Tischkowitz M, Wood M, Yadav S, Yao K, Robson ME
J Clin Oncol 2024 Feb 10;42(5):584-604. Epub 2024 Jan 4 doi: 10.1200/JCO.23.02225. PMID: 38175972
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P
J Thorac Oncol 2022 Feb;17(2):200-213. Epub 2021 Oct 22 doi: 10.1016/j.jtho.2021.10.010. PMID: 34695605
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Huang L, Ma F, Chapman A, Lu S, Xie XS
Annu Rev Genomics Hum Genet 2015;16:79-102. Epub 2015 Jun 11 doi: 10.1146/annurev-genom-090413-025352. PMID: 26077818

Therapy

Bermes M, Rodriguez MJ, de Toledo MAS, Ernst S, Müller-Newen G, Brümmendorf TH, Chatain N, Koschmieder S, Baumeister J
Int J Mol Sci 2023 Dec 16;24(24) doi: 10.3390/ijms242417560. PMID: 38139386Free PMC Article
Geyer CE Jr, Garber JE, Gelber RD, Yothers G, Taboada M, Ross L, Rastogi P, Cui K, Arahmani A, Aktan G, Armstrong AC, Arnedos M, Balmaña J, Bergh J, Bliss J, Delaloge S, Domchek SM, Eisen A, Elsafy F, Fein LE, Fielding A, Ford JM, Friedman S, Gelmon KA, Gianni L, Gnant M, Hollingsworth SJ, Im SA, Jager A, Jóhannsson ÓÞ, Lakhani SR, Janni W, Linderholm B, Liu TW, Loman N, Korde L, Loibl S, Lucas PC, Marmé F, Martinez de Dueñas E, McConnell R, Phillips KA, Piccart M, Rossi G, Schmutzler R, Senkus E, Shao Z, Sharma P, Singer CF, Španić T, Stickeler E, Toi M, Traina TA, Viale G, Zoppoli G, Park YH, Yerushalmi R, Yang H, Pang D, Jung KH, Mailliez A, Fan Z, Tennevet I, Zhang J, Nagy T, Sonke GS, Sun Q, Parton M, Colleoni MA, Schmidt M, Brufsky AM, Razaq W, Kaufman B, Cameron D, Campbell C, Tutt ANJ; OlympiA Clinical Trial Steering Committee and Investigators
Ann Oncol 2022 Dec;33(12):1250-1268. Epub 2022 Oct 10 doi: 10.1016/j.annonc.2022.09.159. PMID: 36228963Free PMC Article
Litton JK, Hurvitz SA, Mina LA, Rugo HS, Lee KH, Gonçalves A, Diab S, Woodward N, Goodwin A, Yerushalmi R, Roché H, Im YH, Eiermann W, Quek RGW, Usari T, Lanzalone S, Czibere A, Blum JL, Martin M, Ettl J
Ann Oncol 2020 Nov;31(11):1526-1535. Epub 2020 Aug 20 doi: 10.1016/j.annonc.2020.08.2098. PMID: 32828825Free PMC Article
Medrano JV, Andrés MDM, García S, Herraiz S, Vilanova-Pérez T, Goossens E, Pellicer A
Trends Biotechnol 2018 Feb;36(2):199-215. Epub 2017 Nov 15 doi: 10.1016/j.tibtech.2017.10.010. PMID: 29153762
Johnsen JI, Kogner P, Albihn A, Henriksson MA
Apoptosis 2009 Apr;14(4):424-38. doi: 10.1007/s10495-009-0325-y. PMID: 19259824

Prognosis

Radford EJ, Tan HK, Andersson MHL, Stephenson JD, Gardner EJ, Ironfield H, Waters AJ, Gitterman D, Lindsay S, Abascal F, Martincorena I, Kolesnik-Taylor A, Ng-Cordell E, Firth HV, Baker K, Perry JRB, Adams DJ, Gerety SS, Hurles ME
Nat Commun 2023 Dec 6;14(1):7702. doi: 10.1038/s41467-023-43041-4. PMID: 38057330Free PMC Article
Gurbuxani S, Hochman MJ, DeZern AE, Shimamura A
Am Soc Clin Oncol Educ Book 2023 Jun;43:e390026. doi: 10.1200/EDBK_390026. PMID: 37307513
Arce S, Athie A, Pritchard CC, Mateo J
Adv Exp Med Biol 2019;1210:279-300. doi: 10.1007/978-3-030-32656-2_12. PMID: 31900913
Vogelsang M, Wilson M, Kirchhoff T
Pigment Cell Melanoma Res 2016 Jan;29(1):15-26. Epub 2015 Nov 3 doi: 10.1111/pcmr.12418. PMID: 26342156Free PMC Article
Harutyunyan AS, Kralovics R
Hematol Oncol Clin North Am 2012 Oct;26(5):1037-51. Epub 2012 Aug 21 doi: 10.1016/j.hoc.2012.07.005. PMID: 23009936

Clinical prediction guides

Bermes M, Rodriguez MJ, de Toledo MAS, Ernst S, Müller-Newen G, Brümmendorf TH, Chatain N, Koschmieder S, Baumeister J
Int J Mol Sci 2023 Dec 16;24(24) doi: 10.3390/ijms242417560. PMID: 38139386Free PMC Article
Radford EJ, Tan HK, Andersson MHL, Stephenson JD, Gardner EJ, Ironfield H, Waters AJ, Gitterman D, Lindsay S, Abascal F, Martincorena I, Kolesnik-Taylor A, Ng-Cordell E, Firth HV, Baker K, Perry JRB, Adams DJ, Gerety SS, Hurles ME
Nat Commun 2023 Dec 6;14(1):7702. doi: 10.1038/s41467-023-43041-4. PMID: 38057330Free PMC Article
Makishima H, Saiki R, Nannya Y, Korotev S, Gurnari C, Takeda J, Momozawa Y, Best S, Krishnamurthy P, Yoshizato T, Atsuta Y, Shiozawa Y, Iijima-Yamashita Y, Yoshida K, Shiraishi Y, Nagata Y, Kakiuchi N, Onizuka M, Chiba K, Tanaka H, Kon A, Ochi Y, Nakagawa MM, Okuda R, Mori T, Yoda A, Itonaga H, Miyazaki Y, Sanada M, Ishikawa T, Chiba S, Tsurumi H, Kasahara S, Müller-Tidow C, Takaori-Kondo A, Ohyashiki K, Kiguchi T, Matsuda F, Jansen JH, Polprasert C, Blombery P, Kamatani Y, Miyano S, Malcovati L, Haferlach T, Kubo M, Cazzola M, Kulasekararaj AG, Godley LA, Maciejewski JP, Ogawa S
Blood 2023 Feb 2;141(5):534-549. doi: 10.1182/blood.2022018221. PMID: 36322930Free PMC Article
Baranwal A, Hahn CN, Shah MV, Hiwase DK
Curr Hematol Malig Rep 2022 Dec;17(6):254-265. Epub 2022 Aug 20 doi: 10.1007/s11899-022-00676-2. PMID: 35986863
Fukami M, Kurahashi H
Methods Mol Biol 2018;1769:21-33. doi: 10.1007/978-1-4939-7780-2_2. PMID: 29564815

Recent systematic reviews

Bedrosian I, Somerfield MR, Achatz MI, Boughey JC, Curigliano G, Friedman S, Kohlmann WK, Kurian AW, Laronga C, Lynce F, Norquist BS, Plichta JK, Rodriguez P, Shah PD, Tischkowitz M, Wood M, Yadav S, Yao K, Robson ME
J Clin Oncol 2024 Feb 10;42(5):584-604. Epub 2024 Jan 4 doi: 10.1200/JCO.23.02225. PMID: 38175972
Fraison E, Huberlant S, Labrune E, Cavalieri M, Montagut M, Brugnon F, Courbiere B
Hum Reprod 2023 Mar 1;38(3):489-502. doi: 10.1093/humrep/deac249. PMID: 36421038Free PMC Article
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
JAMA Netw Open 2019 Nov 1;2(11):e1916318. doi: 10.1001/jamanetworkopen.2019.16318. PMID: 31774524Free PMC Article
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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