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Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder

MedGen UID:
272544
•Concept ID:
C1333293
•
Neoplastic Process
Synonym: Diffuse Large B-Cell Lymphoma PTLD

Definition

A diffuse large B-cell lymphoma that arises in a patient with a history of organ transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086

Recent clinical studies

Etiology

EBV and post-transplant lymphoproliferative disorder: a complex relationship.
El-Mallawany NK, Rouce RH
Hematology Am Soc Hematol Educ Program 2024 Dec 6;2024(1):728-735. doi: 10.1182/hematology.2024000583. PMID: 39644052Free PMC Article
B Cell Lymphomas of the GI Tract.
Small S, Barnea Slonim L, Williams C, Karmali R
Curr Gastroenterol Rep 2021 May 8;23(7):9. doi: 10.1007/s11894-021-00811-8. PMID: 33963950
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-autologous transplant maintenance therapies in lymphoma: current state and future directions.
Riedell PA, Bishop MR
Bone Marrow Transplant 2018 Jan;53(1):11-21. Epub 2017 Oct 2 doi: 10.1038/bmt.2017.196. PMID: 28967896

Diagnosis

Plasmablastic Lymphoma: Past, Present, and Future.
Kaur S, Kollimuttathuillam S
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):e253-e259. Epub 2023 Jun 14 doi: 10.1016/j.clml.2023.05.014. PMID: 37453866
Update on B-cell lymphoproliferative disorders of the gastrointestinal tract.
Plummer RM, Linden MA, Beckman AK
Semin Diagn Pathol 2021 Jul;38(4):14-20. Epub 2021 Mar 26 doi: 10.1053/j.semdp.2021.03.006. PMID: 33863577
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
First Case of Diffuse Large B-Cell Lymphoma Subtype of Monomorphic Post-Transplant Lymphoproliferative Disorder With 3q27 Translocation.
Kim H, Kim IS, Lee EY, Shin DH, Cho SH
Ann Lab Med 2016 Jul;36(4):380-3. doi: 10.3343/alm.2016.36.4.380. PMID: 27139615Free PMC Article

Therapy

EBV and post-transplant lymphoproliferative disorder: a complex relationship.
El-Mallawany NK, Rouce RH
Hematology Am Soc Hematol Educ Program 2024 Dec 6;2024(1):728-735. doi: 10.1182/hematology.2024000583. PMID: 39644052Free PMC Article
CAR T Cell Therapy for Post-Transplant Lymphoproliferative Disorder After Solid Organ Transplantation: A Safe and Feasible Therapy for an Orphan Disease.
Ibrahim U, Bassil C, Chavez JC, Khimani F, Jain MD, Locke FL, Osman K, Lazaryan A
Clin Lymphoma Myeloma Leuk 2023 Oct;23(10):772-778. Epub 2023 May 12 doi: 10.1016/j.clml.2023.05.007. PMID: 37263876
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
An unusual inflammation of the colon. Post-transplant lymphoproliferative disorder (PTLD) and diffuse large B cell lymphoma.
Selinger CP, Howarth G, Willert RP
Gut 2010 Oct;59(10):1393, 1427. Epub 2010 Jun 10 doi: 10.1136/gut.2010.209742. PMID: 20542866

Prognosis

Plasmablastic Lymphoma: Past, Present, and Future.
Kaur S, Kollimuttathuillam S
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):e253-e259. Epub 2023 Jun 14 doi: 10.1016/j.clml.2023.05.014. PMID: 37453866
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Diagnostic, prognostic and therapeutic role of CD30 in lymphoma.
Pierce JM, Mehta A
Expert Rev Hematol 2017 Jan;10(1):29-37. Epub 2016 Dec 21 doi: 10.1080/17474086.2017.1270202. PMID: 27927047
Post-transplant Lymphoproliferative Disorder: A Single-Center Experience.
Ferreira H, Bustorff M, Santos J, Ferreira I, Sampaio S, Salomé I, Bastos J, Bergantim R, Príncipe F, Pestana M
Transplant Proc 2015 May;47(4):981-4. doi: 10.1016/j.transproceed.2015.03.017. PMID: 26036499

Clinical prediction guides

Characteristics and outcomes of children, adolescents and young adults with relapsed/refractory non-hodgkin lymphoma undergoing autologous stem cell transplant.
Pasvolsky O, Bassett RL, Ghanem S, Cuglievan B, Tewari P, Hosing C, Srour S, Ramdial J, Mahadeo KM, Khazal S, Petropoulos D, Popat U, Qazilbash M, Kebriaei P, Champlin R, Shpall EJ, Nieto Y
BMC Cancer 2023 Dec 20;23(1):1258. doi: 10.1186/s12885-023-11712-6. PMID: 38124057Free PMC Article
Identification of high-risk monomorphic post-transplant lymphoproliferative disorder following solid organ transplantation.
Voorhees TJ, Kannan KK, Galeotti J, Grover N, Vaidya R, Moore DT, Montgomery ND, Beaven AW, Dittus C
Leuk Lymphoma 2021 Jan;62(1):86-94. Epub 2020 Sep 16 doi: 10.1080/10428194.2020.1821006. PMID: 32933363
Defective Epstein-Barr virus in chronic active infection and haematological malignancy.
Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H
Nat Microbiol 2019 Mar;4(3):404-413. Epub 2019 Jan 21 doi: 10.1038/s41564-018-0334-0. PMID: 30664667
Mutational landscape of B-cell post-transplant lymphoproliferative disorders.
Menter T, Juskevicius D, Alikian M, Steiger J, Dirnhofer S, Tzankov A, Naresh KN
Br J Haematol 2017 Jul;178(1):48-56. Epub 2017 Apr 17 doi: 10.1111/bjh.14633. PMID: 28419429
Hepatitis C virus - associated B cell non-Hodgkin's lymphoma.
Mihăilă RG
World J Gastroenterol 2016 Jul 21;22(27):6214-23. doi: 10.3748/wjg.v22.i27.6214. PMID: 27468211Free PMC Article

Recent systematic reviews

Post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation: a case report, meta-analysis, and systematic review.
Su YY, Yu YF, Yan ZY, Zhao YJ, Lou JW, Xue F, Xu M, Feng Q, Ji XB, Dong XY, Wang W, Liu CF, Peng J, Liu XG
Diagn Pathol 2024 Sep 7;19(1):122. doi: 10.1186/s13000-024-01544-8. PMID: 39244586Free PMC Article
CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review.
Portuguese AJ, Gauthier J, Tykodi SS, Hall ET, Hirayama AV, Yeung CCS, Blosser CD
Bone Marrow Transplant 2023 Apr;58(4):353-359. Epub 2022 Dec 27 doi: 10.1038/s41409-022-01907-z. PMID: 36575360
Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review.
Berger GK, McBride A, Lawson S, Royball K, Yun S, Gee K, Bin Riaz I, Saleh AA, Puvvada S, Anwer F
Crit Rev Oncol Hematol 2017 Jan;109:42-50. Epub 2016 Nov 21 doi: 10.1016/j.critrevonc.2016.11.009. PMID: 28010897Free PMC Article

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