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Aggressive B-cell non-Hodgkin lymphoma

MedGen UID:
1791561
Concept ID:
C5555120
Neoplastic Process
Synonyms: Aggressive B-cell NHL; aggressive B-cell NHL; Aggressive B-Cell Non-Hodgkin Lymphoma; aggressive B-cell non-Hodgkin lymphoma
 
Monarch Initiative: MONDO:0017595
Orphanet: ORPHA300846

Definition

A B-cell non-Hodgkin lymphoma with an aggressive clinical course. This category includes B lymphoblastic lymphoma, subtypes of diffuse large B-cell lymphoma, Burkitt lymphoma, grade 3 follicular lymphoma, and mantle cell lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAggressive B-cell non-Hodgkin lymphoma

Professional guidelines

PubMed

Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Chen R, Sanchez J, Rosen ST
Oncology (Williston Park) 2016 Apr;30(4):353-60. PMID: 27083466

Recent clinical studies

Etiology

Budde LE, Assouline S, Sehn LH, Schuster SJ, Yoon SS, Yoon DH, Matasar MJ, Bosch F, Kim WS, Nastoupil LJ, Flinn IW, Shadman M, Diefenbach C, Cheah CY, Ma CY, Huang H, Kwan A, Wei MC, Yin S, Bartlett NL
J Clin Oncol 2024 Jul 1;42(19):2250-2256. Epub 2024 Mar 28 doi: 10.1200/JCO.23.02329. PMID: 38547425Free PMC Article
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ
Blood 2019 Apr 25;133(17):1876-1887. Epub 2019 Feb 19 doi: 10.1182/blood-2018-11-887067. PMID: 30782611Free PMC Article
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947

Diagnosis

Toner K, McCann CD, Bollard CM
Nat Rev Clin Oncol 2024 Oct;21(10):709-724. Epub 2024 Aug 19 doi: 10.1038/s41571-024-00930-x. PMID: 39160243
Khanmohammadi S, Fallahtafti P
J Cell Mol Med 2023 Jul;27(14):1928-1946. Epub 2023 May 29 doi: 10.1111/jcmm.17795. PMID: 37246627Free PMC Article
Bailly J, Jenkins N, Chetty D, Mohamed Z, Verburgh ER, Opie JJ
Int J Lab Hematol 2022 Sep;44 Suppl 1(Suppl 1):54-63. doi: 10.1111/ijlh.13863. PMID: 36074710Free PMC Article
Moleti ML, Testi AM, Foà R
Br J Haematol 2022 Feb;196(4):849-863. Epub 2021 Dec 6 doi: 10.1111/bjh.17979. PMID: 34866182
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Therapy

Zhang J, Hu Y, Yang J, Li W, Zhang M, Wang Q, Zhang L, Wei G, Tian Y, Zhao K, Chen A, Tan B, Cui J, Li D, Li Y, Qi Y, Wang D, Wu Y, Li D, Du B, Liu M, Huang H
Nature 2022 Sep;609(7926):369-374. Epub 2022 Aug 31 doi: 10.1038/s41586-022-05140-y. PMID: 36045296Free PMC Article
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947

Prognosis

Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Poeschel V, Held G, Ziepert M, Witzens-Harig M, Holte H, Thurner L, Borchmann P, Viardot A, Soekler M, Keller U, Schmidt C, Truemper L, Mahlberg R, Marks R, Hoeffkes HG, Metzner B, Dierlamm J, Frickhofen N, Haenel M, Neubauer A, Kneba M, Merli F, Tucci A, de Nully Brown P, Federico M, Lengfelder E, di Rocco A, Trappe R, Rosenwald A, Berdel C, Maisenhoelder M, Shpilberg O, Amam J, Christofyllakis K, Hartmann F, Murawski N, Stilgenbauer S, Nickelsen M, Wulf G, Glass B, Schmitz N, Altmann B, Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance
Lancet 2019 Dec 21;394(10216):2271-2281. doi: 10.1016/S0140-6736(19)33008-9. PMID: 31868632
Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ
Blood 2019 Apr 25;133(17):1876-1887. Epub 2019 Feb 19 doi: 10.1182/blood-2018-11-887067. PMID: 30782611Free PMC Article
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947

Clinical prediction guides

Budde LE, Assouline S, Sehn LH, Schuster SJ, Yoon SS, Yoon DH, Matasar MJ, Bosch F, Kim WS, Nastoupil LJ, Flinn IW, Shadman M, Diefenbach C, Cheah CY, Ma CY, Huang H, Kwan A, Wei MC, Yin S, Bartlett NL
J Clin Oncol 2024 Jul 1;42(19):2250-2256. Epub 2024 Mar 28 doi: 10.1200/JCO.23.02329. PMID: 38547425Free PMC Article
Zhang J, Hu Y, Yang J, Li W, Zhang M, Wang Q, Zhang L, Wei G, Tian Y, Zhao K, Chen A, Tan B, Cui J, Li D, Li Y, Qi Y, Wang D, Wu Y, Li D, Du B, Liu M, Huang H
Nature 2022 Sep;609(7926):369-374. Epub 2022 Aug 31 doi: 10.1038/s41586-022-05140-y. PMID: 36045296Free PMC Article
Makita S, Yamamoto G, Maruyama D, Asano-Mori Y, Kaji D, Ananthakrishnan R, Ogasawara K, Stepan L, Schusterbauer C, Rettby N, Hasskarl J, Izutsu K
Cancer Med 2022 Dec;11(24):4889-4899. Epub 2022 May 26 doi: 10.1002/cam4.4820. PMID: 35619325Free PMC Article
Chandramohan J, Ganapule G, Sigamani E, George B, Korula A, Manipadam MT
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):381-386. doi: 10.4103/IJPM.IJPM_1384_20. PMID: 35435375
Wei J, Xiao M, Mao Z, Wang N, Cao Y, Xiao Y, Meng F, Sun W, Wang Y, Yang X, Chen L, Zhang Y, Zhu H, Zhang S, Zhang T, Zhou J, Huang L
Signal Transduct Target Ther 2022 Apr 11;7(1):101. doi: 10.1038/s41392-022-00924-0. PMID: 35399106Free PMC Article

Recent systematic reviews

Khanmohammadi S, Fallahtafti P
J Cell Mol Med 2023 Jul;27(14):1928-1946. Epub 2023 May 29 doi: 10.1111/jcmm.17795. PMID: 37246627Free PMC Article
Epperla N, Hamadani M, Reljic T, Kharfan-Dabaja MA, Savani BN, Kumar A
Cancer 2019 Dec 15;125(24):4417-4425. Epub 2019 Aug 23 doi: 10.1002/cncr.32464. PMID: 31441943

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