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Functioning endocrine neoplasm

MedGen UID:
458881
•Concept ID:
C2986655
•
Neoplastic Process
Synonyms: Functioning Endocrine Neoplasm; functioning endocrine neoplasm; functioning tumor; functioning tumour
 
Monarch Initiative: MONDO:0021120

Definition

A hormone producing endocrine neoplasm, associated with a hormonal syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFunctioning endocrine neoplasm

Professional guidelines

PubMed

European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors.
Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M, Kos-Kudla B, Kwekkeboom D, Rindi G, Klöppel G, Reed N, Kianmanesh R, Jensen RT; Vienna Consensus Conference participants
Neuroendocrinology 2016;103(2):153-71. Epub 2016 Jan 5 doi: 10.1159/000443171. PMID: 26742109Free PMC Article
Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.
Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society
J Clin Endocrinol Metab 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498. PMID: 24893135

Recent clinical studies

Etiology

New perspectives for mitotane treatment of adrenocortical carcinoma.
Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P, Terzolo M
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101415. Epub 2020 Mar 5 doi: 10.1016/j.beem.2020.101415. PMID: 32179008
Perioperative Management of Endocrine Active Adrenal Tumors.
Schreiner F, Anand G, Beuschlein F
Exp Clin Endocrinol Diabetes 2019 Feb;127(2-03):137-146. Epub 2018 Aug 14 doi: 10.1055/a-0654-5251. PMID: 30107625
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article
Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.
Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society
J Clin Endocrinol Metab 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498. PMID: 24893135

Diagnosis

Neuroendocrine Neoplasms.
Kamboj S, Guerra-Bauman F, Mahmud H, Waheed A
Prim Care 2024 Sep;51(3):549-560. Epub 2024 May 23 doi: 10.1016/j.pop.2024.04.010. PMID: 39067978
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Adrenal Incidentaloma.
Sherlock M, Scarsbrook A, Abbas A, Fraser S, Limumpornpetch P, Dineen R, Stewart PM
Endocr Rev 2020 Dec 1;41(6):775-820. doi: 10.1210/endrev/bnaa008. PMID: 32266384Free PMC Article
The incidental thyroid nodule.
Fisher SB, Perrier ND
CA Cancer J Clin 2018 Mar;68(2):97-105. Epub 2018 Jan 25 doi: 10.3322/caac.21447. PMID: 29369334
Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.
Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society
J Clin Endocrinol Metab 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498. PMID: 24893135

Therapy

Pediatric adrenocortical carcinoma.
Ilanchezhian M, Varghese DG, Glod JW, Reilly KM, Widemann BC, Pommier Y, Kaplan RN, Del Rivero J
Front Endocrinol (Lausanne) 2022;13:961650. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.961650. PMID: 36387865Free PMC Article
Immunotherapy for pancreatic ductal adenocarcinoma.
Carpenter E, Nelson S, Bednar F, Cho C, Nathan H, Sahai V, di Magliano MP, Frankel TL
J Surg Oncol 2021 Mar;123(3):751-759. doi: 10.1002/jso.26312. PMID: 33595893
Challenges and Opportunities for Pancreatic Cancer Immunotherapy.
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591

Prognosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Applications of Immunohistochemistry to Endocrine Pathology.
Higgins SE, Barletta JA
Adv Anat Pathol 2018 Nov;25(6):413-429. doi: 10.1097/PAP.0000000000000209. PMID: 30157042
Nonfunctional pancreatic neuroendocrine tumors.
Kuo JH, Lee JA, Chabot JA
Surg Clin North Am 2014 Jun;94(3):689-708. Epub 2014 Apr 13 doi: 10.1016/j.suc.2014.02.010. PMID: 24857584
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article
Insulinoma.
Grant CS
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):783-98. doi: 10.1016/j.bpg.2005.05.008. PMID: 16253900

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
The incidental thyroid nodule.
Fisher SB, Perrier ND
CA Cancer J Clin 2018 Mar;68(2):97-105. Epub 2018 Jan 25 doi: 10.3322/caac.21447. PMID: 29369334
The 2017 Bethesda System for Reporting Thyroid Cytopathology.
Cibas ES, Ali SZ
Thyroid 2017 Nov;27(11):1341-1346. doi: 10.1089/thy.2017.0500. PMID: 29091573
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent systematic reviews

Prevalence and Impact of BRAF mutation in patients with concomitant papillary thyroid carcinoma and Hashimoto's thyroiditis: a systematic review with meta-analysis.
Janicki L, Patel A, Jendrzejewski J, Hellmann A
Front Endocrinol (Lausanne) 2023;14:1273498. Epub 2023 Nov 17 doi: 10.3389/fendo.2023.1273498. PMID: 38047109Free PMC Article
Comorbidities in mild autonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis.
Pelsma ICM, Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Oct 17;189(4):S88-S101. doi: 10.1093/ejendo/lvad134. PMID: 37801655
Diagnosis and management of parathyroid carcinoma: a state-of-the-art review.
Roser P, Leca BM, Coelho C, Schulte KM, Gilbert J, Drakou EE, Kosmas C, Ling Chuah L, Wassati H, Miras AD, Crane J, Aylwin SJB, Grossman AB, Dimitriadis GK
Endocr Relat Cancer 2023 Apr 1;30(4) Epub 2023 Mar 22 doi: 10.1530/ERC-22-0287. PMID: 36621911
A systematic review and meta-analysis of the association between circulating tumor DNA (ctDNA) and prognosis in pancreatic cancer.
Guven DC, Sahin TK, Yildirim HC, Aktepe OH, Dizdar O, Yalcin S
Crit Rev Oncol Hematol 2021 Dec;168:103528. Epub 2021 Nov 17 doi: 10.1016/j.critrevonc.2021.103528. PMID: 34800650
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article

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