U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Childhood Acute Myeloid Leukemia Not Otherwise Specified

MedGen UID:
889446
Concept ID:
C4055251
Neoplastic Process
Synonym: Childhood Acute Myeloid Leukemia Defined by Differentiation

Definition

Acute myeloid leukemias that occur in childhood and do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related. This category includes entities classified according to the French-American-British classification scheme. [from NCI]

Professional guidelines

PubMed

Namazzi R, Gaikwad A, Wasswa P, Cubbage M, Kambugu JB, Kasirye P, Geriga F, Allen C, Lubega J
Blood Adv 2018 Nov 30;2(Suppl 1):21-23. doi: 10.1182/bloodadvances.2018GS112620. PMID: 30504192Free PMC Article
Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, Harbott J, Hasle H, Johnston D, Kinoshita A, Lehrnbecher T, Leverger G, Mejstrikova E, Meshinchi S, Pession A, Raimondi SC, Sung L, Stary J, Zwaan CM, Kaspers GJ, Reinhardt D; AML Committee of the International BFM Study Group
Blood 2012 Oct 18;120(16):3187-205. Epub 2012 Aug 9 doi: 10.1182/blood-2012-03-362608. PMID: 22879540
Creutzig U
Crit Rev Oncol Hematol 1996 Apr;22(3):183-96. doi: 10.1016/1040-8428(96)00195-3. PMID: 8793274

Recent clinical studies

Etiology

Kintossou AK, Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Kozlakidis Z, Huybrechts I
Nutrients 2023 Aug 29;15(17) doi: 10.3390/nu15173775. PMID: 37686807Free PMC Article
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M
Blood 2022 Nov 24;140(21):2228-2247. doi: 10.1182/blood.2022015853. PMID: 36130297Free PMC Article
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960

Diagnosis

Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M
Blood 2022 Nov 24;140(21):2228-2247. doi: 10.1182/blood.2022015853. PMID: 36130297Free PMC Article
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, Harbott J, Hasle H, Johnston D, Kinoshita A, Lehrnbecher T, Leverger G, Mejstrikova E, Meshinchi S, Pession A, Raimondi SC, Sung L, Stary J, Zwaan CM, Kaspers GJ, Reinhardt D; AML Committee of the International BFM Study Group
Blood 2012 Oct 18;120(16):3187-205. Epub 2012 Aug 9 doi: 10.1182/blood-2012-03-362608. PMID: 22879540

Therapy

Bhagwat AS, Torres L, Shestova O, Shestov M, Mellors PW, Fisher HR, Farooki SN, Frost BF, Loken MR, Gaymon AL, Frazee D, Rogal W, Frey N, Hexner EO, Luger SM, Loren AW, Martin ME, McCurdy SR, Perl AE, Stadtmauer EA, Brogdon JL, Fraietta JA, Hwang WT, Siegel DL, Plesa G, Aplenc R, Porter DL, June CH, Gill SI
Nat Med 2024 Dec;30(12):3697-3708. Epub 2024 Sep 27 doi: 10.1038/s41591-024-03271-5. PMID: 39333315
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Zhu HH, Qin YZ, Zhang ZL, Liu YJ, Wen LJ, You MJ, Zhang C, Such E, Luo H, Yuan HJ, Zhou HS, Liu HX, Xu R, Li J, Li JH, Hao JP, Jin J, Yu L, Zhang JY, Liu LP, Zhang LP, Huang RB, Shen SH, Gao SJ, Wang W, Yan XJ, Zhang XY, Du X, Chu XX, Yu YF, Wang Y, Mi YC, Lu Y, Cai Z, Su Z, Taussig DC, MacMahon S, Ball ED, Wang HY, Welch JS, Yin CC, Borthakur G, Sanz MA, Kantarjian HM, Huang JY, Hu J, Chen SN
Blood Adv 2023 Jul 11;7(13):2972-2982. doi: 10.1182/bloodadvances.2022008364. PMID: 36799929Free PMC Article
Vadakekolathu J, Minden MD, Hood T, Church SE, Reeder S, Altmann H, Sullivan AH, Viboch EJ, Patel T, Ibrahimova N, Warren SE, Arruda A, Liang Y, Smith TH, Foulds GA, Bailey MD, Gowen-MacDonald J, Muth J, Schmitz M, Cesano A, Pockley AG, Valk PJM, Löwenberg B, Bornhäuser M, Tasian SK, Rettig MP, Davidson-Moncada JK, DiPersio JF, Rutella S
Sci Transl Med 2020 Jun 3;12(546) doi: 10.1126/scitranslmed.aaz0463. PMID: 32493790Free PMC Article
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781

Prognosis

Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K
Cell 2024 Jun 6;187(12):3120-3140.e29. Epub 2024 May 6 doi: 10.1016/j.cell.2024.04.013. PMID: 38714197Free PMC Article
Zhu HH, Qin YZ, Zhang ZL, Liu YJ, Wen LJ, You MJ, Zhang C, Such E, Luo H, Yuan HJ, Zhou HS, Liu HX, Xu R, Li J, Li JH, Hao JP, Jin J, Yu L, Zhang JY, Liu LP, Zhang LP, Huang RB, Shen SH, Gao SJ, Wang W, Yan XJ, Zhang XY, Du X, Chu XX, Yu YF, Wang Y, Mi YC, Lu Y, Cai Z, Su Z, Taussig DC, MacMahon S, Ball ED, Wang HY, Welch JS, Yin CC, Borthakur G, Sanz MA, Kantarjian HM, Huang JY, Hu J, Chen SN
Blood Adv 2023 Jul 11;7(13):2972-2982. doi: 10.1182/bloodadvances.2022008364. PMID: 36799929Free PMC Article
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, Harbott J, Hasle H, Johnston D, Kinoshita A, Lehrnbecher T, Leverger G, Mejstrikova E, Meshinchi S, Pession A, Raimondi SC, Sung L, Stary J, Zwaan CM, Kaspers GJ, Reinhardt D; AML Committee of the International BFM Study Group
Blood 2012 Oct 18;120(16):3187-205. Epub 2012 Aug 9 doi: 10.1182/blood-2012-03-362608. PMID: 22879540
Greaves M
BMJ 2002 Feb 2;324(7332):283-7. doi: 10.1136/bmj.324.7332.283. PMID: 11823363Free PMC Article

Clinical prediction guides

Bhagwat AS, Torres L, Shestova O, Shestov M, Mellors PW, Fisher HR, Farooki SN, Frost BF, Loken MR, Gaymon AL, Frazee D, Rogal W, Frey N, Hexner EO, Luger SM, Loren AW, Martin ME, McCurdy SR, Perl AE, Stadtmauer EA, Brogdon JL, Fraietta JA, Hwang WT, Siegel DL, Plesa G, Aplenc R, Porter DL, June CH, Gill SI
Nat Med 2024 Dec;30(12):3697-3708. Epub 2024 Sep 27 doi: 10.1038/s41591-024-03271-5. PMID: 39333315
Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K
Cell 2024 Jun 6;187(12):3120-3140.e29. Epub 2024 May 6 doi: 10.1016/j.cell.2024.04.013. PMID: 38714197Free PMC Article
Gao L, Tober J, Gao P, Chen C, Tan K, Speck NA
Exp Hematol 2018 Dec;68:2-9. Epub 2018 Oct 31 doi: 10.1016/j.exphem.2018.10.009. PMID: 30391350Free PMC Article
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article

Recent systematic reviews

Kintossou AK, Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Kozlakidis Z, Huybrechts I
Nutrients 2023 Aug 29;15(17) doi: 10.3390/nu15173775. PMID: 37686807Free PMC Article
Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Huybrechts I
Int J Environ Res Public Health 2023 Apr 6;20(7) doi: 10.3390/ijerph20075428. PMID: 37048042Free PMC Article
de Baat EC, Mulder RL, Armenian S, Feijen EA, Grotenhuis H, Hudson MM, Mavinkurve-Groothuis AM, Kremer LC, van Dalen EC
Cochrane Database Syst Rev 2022 Sep 27;9(9):CD014638. doi: 10.1002/14651858.CD014638.pub2. PMID: 36162822Free PMC Article
Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208
Segerink WH, de Haas V, Kaspers GJL
Expert Rev Anticancer Ther 2021 Apr;21(4):451-459. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1860763. PMID: 33706635

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...