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Non-Langerhans cell histiocytosis

MedGen UID:
9265
Concept ID:
C0019624
Disease or Syndrome
Synonyms: Histiocytosis, Non Langerhans Cell; Histiocytosis, Non-Langerhans-Cell; Non-Langerhans-Cell Histiocytosis
 
Monarch Initiative: MONDO:0015531
Orphanet: ORPHA157987

Definition

Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; juvenile XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES). [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Langerhans cell histiocytosis
Follow this link to review classifications for Non-Langerhans cell histiocytosis in Orphanet.

Professional guidelines

PubMed

Aaroe A, Kurzrock R, Goyal G, Goodman AM, Patel H, Ruan G, Ulaner G, Young J, Li Z, Dustin D, Go RS, Diamond EL, Janku F
Blood Adv 2023 Aug 8;7(15):3984-3992. doi: 10.1182/bloodadvances.2022009013. PMID: 36857436Free PMC Article
Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile JF, Durham BH, Braier J, Charlotte F, Donadieu J, Cohen-Aubart F, Rodriguez-Galindo C, Allen C, Whitlock JA, Weitzman S, McClain KL, Haroche J, Diamond EL
Blood 2018 Jun 28;131(26):2877-2890. Epub 2018 May 2 doi: 10.1182/blood-2018-03-839753. PMID: 29720485Free PMC Article
Munoz J, Janku F, Cohen PR, Kurzrock R
Mayo Clin Proc 2014 Jul;89(7):985-96. Epub 2014 May 9 doi: 10.1016/j.mayocp.2014.01.023. PMID: 24814521

Recent clinical studies

Etiology

Garcia-Sirvent L, Espineira-Sicre J, Ruiz-Sanchez J, Cuesta-Montero L
Dermatol Online J 2024 Mar 15;30(1) doi: 10.5070/D330163291. PMID: 38762861
Chi SN, Yi JS, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Jaju A, Mhlanga JC, Fox E, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
J Natl Cancer Inst 2023 Nov 8;115(11):1355-1363. doi: 10.1093/jnci/djad085. PMID: 37228094Free PMC Article
Fraitag S, Emile JF
Histopathology 2022 Jan;80(1):196-215. doi: 10.1111/his.14569. PMID: 34958507
Hernández-San Martín MJ, Vargas-Mora P, Aranibar L
Actas Dermosifiliogr (Engl Ed) 2020 Nov;111(9):725-733. Epub 2020 Jul 25 doi: 10.1016/j.ad.2020.07.004. PMID: 32721389
Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile JF, Durham BH, Braier J, Charlotte F, Donadieu J, Cohen-Aubart F, Rodriguez-Galindo C, Allen C, Whitlock JA, Weitzman S, McClain KL, Haroche J, Diamond EL
Blood 2018 Jun 28;131(26):2877-2890. Epub 2018 May 2 doi: 10.1182/blood-2018-03-839753. PMID: 29720485Free PMC Article

Diagnosis

Garcia-Sirvent L, Espineira-Sicre J, Ruiz-Sanchez J, Cuesta-Montero L
Dermatol Online J 2024 Mar 15;30(1) doi: 10.5070/D330163291. PMID: 38762861
Benson JC, Vaubel R, Ebne BA, Mark IT, Peris Celda M, Hook CC, Tobin WO, Giannini C
AJNR Am J Neuroradiol 2023 May;44(5):505-510. Epub 2023 Mar 30 doi: 10.3174/ajnr.A7832. PMID: 36997288Free PMC Article
Hernández-San Martín MJ, Vargas-Mora P, Aranibar L
Actas Dermosifiliogr (Engl Ed) 2020 Nov;111(9):725-733. Epub 2020 Jul 25 doi: 10.1016/j.ad.2020.07.004. PMID: 32721389
Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile JF, Durham BH, Braier J, Charlotte F, Donadieu J, Cohen-Aubart F, Rodriguez-Galindo C, Allen C, Whitlock JA, Weitzman S, McClain KL, Haroche J, Diamond EL
Blood 2018 Jun 28;131(26):2877-2890. Epub 2018 May 2 doi: 10.1182/blood-2018-03-839753. PMID: 29720485Free PMC Article
Haroche J, Arnaud L, Cohen-Aubart F, Hervier B, Charlotte F, Emile JF, Amoura Z
Rheum Dis Clin North Am 2013 May;39(2):299-311. Epub 2013 Mar 14 doi: 10.1016/j.rdc.2013.02.011. PMID: 23597965

Therapy

Steinhelfer L, Kühnel T, Jägle H, Mayer S, Karrer S, Haubner F, Schreml S
Orphanet J Rare Dis 2022 Mar 24;17(1):132. doi: 10.1186/s13023-022-02291-z. PMID: 35331271Free PMC Article
Francis JH, Gobin YP, Alshiekh Nasany R, Knopman J, Ulaner GA, Panageas KS, Hatzoglou V, Salvaggio K, Abramson DH, Patsalides A, Diamond EL
Neurology 2021 Jun 8;96(23):1091-1093. Epub 2021 May 12 doi: 10.1212/WNL.0000000000012070. PMID: 33980709Free PMC Article
Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile JF, Durham BH, Braier J, Charlotte F, Donadieu J, Cohen-Aubart F, Rodriguez-Galindo C, Allen C, Whitlock JA, Weitzman S, McClain KL, Haroche J, Diamond EL
Blood 2018 Jun 28;131(26):2877-2890. Epub 2018 May 2 doi: 10.1182/blood-2018-03-839753. PMID: 29720485Free PMC Article
Diamond EL, Durham BH, Haroche J, Yao Z, Ma J, Parikh SA, Wang Z, Choi J, Kim E, Cohen-Aubart F, Lee SC, Gao Y, Micol JB, Campbell P, Walsh MP, Sylvester B, Dolgalev I, Aminova O, Heguy A, Zappile P, Nakitandwe J, Ganzel C, Dalton JD, Ellison DW, Estrada-Veras J, Lacouture M, Gahl WA, Stephens PJ, Miller VA, Ross JS, Ali SM, Briggs SR, Fasan O, Block J, Héritier S, Donadieu J, Solit DB, Hyman DM, Baselga J, Janku F, Taylor BS, Park CY, Amoura Z, Dogan A, Emile JF, Rosen N, Gruber TA, Abdel-Wahab O
Cancer Discov 2016 Feb;6(2):154-65. Epub 2015 Nov 13 doi: 10.1158/2159-8290.CD-15-0913. PMID: 26566875Free PMC Article
Haroche J, Arnaud L, Cohen-Aubart F, Hervier B, Charlotte F, Emile JF, Amoura Z
Rheum Dis Clin North Am 2013 May;39(2):299-311. Epub 2013 Mar 14 doi: 10.1016/j.rdc.2013.02.011. PMID: 23597965

Prognosis

Das JP, Xie L, Riedl CC, Hayes SA, Ginsberg MS, Halpenny DF
Br J Radiol 2019 Dec;92(1104):20190473. Epub 2019 Aug 14 doi: 10.1259/bjr.20190473. PMID: 31386554Free PMC Article
Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile JF, Durham BH, Braier J, Charlotte F, Donadieu J, Cohen-Aubart F, Rodriguez-Galindo C, Allen C, Whitlock JA, Weitzman S, McClain KL, Haroche J, Diamond EL
Blood 2018 Jun 28;131(26):2877-2890. Epub 2018 May 2 doi: 10.1182/blood-2018-03-839753. PMID: 29720485Free PMC Article
Goupil de Bouillé J, de Muret A, Diot E, Dumont P, Plantier L, Diot P, Marchand-Adam S
Sarcoidosis Vasc Diffuse Lung Dis 2015 Sep 14;32(3):275-7. PMID: 26422575
Haroche J, Arnaud L, Cohen-Aubart F, Hervier B, Charlotte F, Emile JF, Amoura Z
Rheum Dis Clin North Am 2013 May;39(2):299-311. Epub 2013 Mar 14 doi: 10.1016/j.rdc.2013.02.011. PMID: 23597965
Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB
J Am Acad Dermatol 1997 Mar;36(3 Pt 1):355-67; quiz 368-9. doi: 10.1016/s0190-9622(97)80207-1. PMID: 9091465

Clinical prediction guides

Chi SN, Yi JS, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Jaju A, Mhlanga JC, Fox E, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
J Natl Cancer Inst 2023 Nov 8;115(11):1355-1363. doi: 10.1093/jnci/djad085. PMID: 37228094Free PMC Article
Chazal T, Pegoraro F, Manari G, Bettiol A, Maniscalco V, Gelain E, Charlotte F, Mazor RD, Renard-Penna R, Amoura Z, Cohen-Aubart F, Haroche J, Izzedine H, Vaglio A
Kidney Int 2023 Jan;103(1):177-186. Epub 2022 Oct 27 doi: 10.1016/j.kint.2022.09.027. PMID: 36374823
Abla O, Jacobsen E, Picarsic J, Krenova Z, Jaffe R, Emile JF, Durham BH, Braier J, Charlotte F, Donadieu J, Cohen-Aubart F, Rodriguez-Galindo C, Allen C, Whitlock JA, Weitzman S, McClain KL, Haroche J, Diamond EL
Blood 2018 Jun 28;131(26):2877-2890. Epub 2018 May 2 doi: 10.1182/blood-2018-03-839753. PMID: 29720485Free PMC Article
Goupil de Bouillé J, de Muret A, Diot E, Dumont P, Plantier L, Diot P, Marchand-Adam S
Sarcoidosis Vasc Diffuse Lung Dis 2015 Sep 14;32(3):275-7. PMID: 26422575
Berti A, Ferrarini M, Ferrero E, Dagna L
Clin Exp Rheumatol 2015 Mar-Apr;33(2 Suppl 89):S-155-63. Epub 2015 Feb 18 PMID: 25738753

Recent systematic reviews

Mija LA, Zhu CK, Mukovozov I
J Cutan Med Surg 2024 Nov-Dec;28(6):572-576. Epub 2024 Aug 27 doi: 10.1177/12034754241274356. PMID: 39192594Free PMC Article
Steinhelfer L, Kühnel T, Jägle H, Mayer S, Karrer S, Haubner F, Schreml S
Orphanet J Rare Dis 2022 Mar 24;17(1):132. doi: 10.1186/s13023-022-02291-z. PMID: 35331271Free PMC Article
Nelson CA, Zhong CS, Hashemi DA, Ashchyan HJ, Brown-Joel Z, Noe MH, Imadojemu S, Micheletti RG, Vleugels RA, Wanat KA, Rosenbach M, Mostaghimi A
JAMA Dermatol 2020 Mar 1;156(3):270-279. doi: 10.1001/jamadermatol.2019.4221. PMID: 31940000Free PMC Article
Miguel D, Lukacs J, Illing T, Elsner P
J Eur Acad Dermatol Venereol 2017 Feb;31(2):221-235. Epub 2016 Jul 19 doi: 10.1111/jdv.13786. PMID: 27436448
Cives M, Simone V, Rizzo FM, Dicuonzo F, Cristallo Lacalamita M, Ingravallo G, Silvestris F, Dammacco F
Crit Rev Oncol Hematol 2015 Jul;95(1):1-11. Epub 2015 Feb 17 doi: 10.1016/j.critrevonc.2015.02.004. PMID: 25744785

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