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Recurrent Leukemia

MedGen UID:
1652854
•Concept ID:
C0920028
•
Neoplastic Process

Definition

The reemergence of leukemia after a period of remission. [from NCI]

Professional guidelines

PubMed

Neoplastic meningitis: diagnosis and treatment considerations.
Blaney SM, Poplack DG
Med Oncol 2000 Aug;17(3):151-62. doi: 10.1007/BF02780522. PMID: 10962524
Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia.
Sullivan KM, Weiden PL, Storb R, Witherspoon RP, Fefer A, Fisher L, Buckner CD, Anasetti C, Appelbaum FR, Badger C
Blood 1989 May 1;73(6):1720-8. PMID: 2653460
Facial paralysis in children: differential diagnosis.
May M, Fria TJ, Blumenthal F, Curtin H
Otolaryngol Head Neck Surg 1981 Sep-Oct;89(5):841-8. doi: 10.1177/019459988108900528. PMID: 6799919

Recent clinical studies

Etiology

Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant?
Eapen M
Best Pract Res Clin Haematol 2017 Dec;30(4):317-319. Epub 2017 Sep 22 doi: 10.1016/j.beha.2017.09.007. PMID: 29156202
Up-regulation of VEGF and its receptor in refractory leukemia cells.
Wang L, Zhang W, Ding Y, Xiu B, Li P, Dong Y, Zhu Q, Liang A
Int J Clin Exp Pathol 2015;8(5):5282-90. Epub 2015 May 1 PMID: 26191229Free PMC Article
T-cell depleted allogeneic hematopoietic cell transplants as a platform for adoptive therapy with leukemia selective or virus-specific T-cells.
O'Reilly RJ, Koehne G, Hasan AN, Doubrovina E, Prockop S
Bone Marrow Transplant 2015 Jun;50 Suppl 2(Suppl 2):S43-50. doi: 10.1038/bmt.2015.95. PMID: 26039207Free PMC Article
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.
Yang XJ
Nucleic Acids Res 2004;32(3):959-76. Epub 2004 Feb 11 doi: 10.1093/nar/gkh252. PMID: 14960713Free PMC Article
Recurrence of acute leukemia more than two years after allogeneic marrow grafting.
Witherspoon R, Flournoy N, Thomas ED, Ramberg R, Buckner CD, Storb R
Exp Hematol 1986 Mar;14(3):178-81. PMID: 3512278

Diagnosis

Preleukemia: the normal side of cancer.
Shlush LI, Minden MD
Curr Opin Hematol 2015 Mar;22(2):77-84. doi: 10.1097/MOH.0000000000000111. PMID: 25575035
Acute basophilic leukemia.
Giagounidis AA, Hildebrandt B, Heinsch M, Germing U, Aivado M, Aul C
Eur J Haematol 2001 Aug;67(2):72-6. doi: 10.1034/j.1600-0609.2001.t01-1-00487.x. PMID: 11722593
Analysis of chimerism within specific leukocyte subsets for detection of residual or recurrent leukemia in pediatric patients after allogeneic stem cell transplantation.
Lion T, Daxberger H, Dubovsky J, Filipcik P, Fritsch G, Printz D, Peters C, Matthes-Martin S, Lawitschka A, Gadner H
Leukemia 2001 Feb;15(2):307-10. doi: 10.1038/sj.leu.2402017. PMID: 11236951
Neoplastic meningitis: diagnosis and treatment considerations.
Blaney SM, Poplack DG
Med Oncol 2000 Aug;17(3):151-62. doi: 10.1007/BF02780522. PMID: 10962524
Herpes simplex thymidine kinase (HStk) transgenic donor lymphocytes.
Burt RK, Drobyski WR, Traynor AE, Link CJ Jr
Bone Marrow Transplant 1999 Nov;24(10):1043-51. doi: 10.1038/sj.bmt.1702020. PMID: 10578153

Therapy

HA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation.
Krakow EF, Brault M, Summers C, Cunningham TM, Biernacki MA, Black RG, Woodward KB, Vartanian N, Kanaan SB, Yeh AC, Dossa RG, Bar M, Cassaday RD, Dahlberg A, Till BG, Denker AE, Yeung CCS, Gooley TA, Maloney DG, Riddell SR, Greenberg PD, Chapuis AG, Newell EW, Furlan SN, Bleakley M
Blood 2024 Sep 5;144(10):1069-1082. doi: 10.1182/blood.2024024105. PMID: 38683966Free PMC Article
Acute basophilic leukemia.
Giagounidis AA, Hildebrandt B, Heinsch M, Germing U, Aivado M, Aul C
Eur J Haematol 2001 Aug;67(2):72-6. doi: 10.1034/j.1600-0609.2001.t01-1-00487.x. PMID: 11722593
Neoplastic meningitis: diagnosis and treatment considerations.
Blaney SM, Poplack DG
Med Oncol 2000 Aug;17(3):151-62. doi: 10.1007/BF02780522. PMID: 10962524
Herpes simplex thymidine kinase (HStk) transgenic donor lymphocytes.
Burt RK, Drobyski WR, Traynor AE, Link CJ Jr
Bone Marrow Transplant 1999 Nov;24(10):1043-51. doi: 10.1038/sj.bmt.1702020. PMID: 10578153
Donor leukocyte transfusions for leukemic relapse.
van Rhee F, Kolb HJ
Curr Opin Hematol 1995 Nov;2(6):423-30. doi: 10.1097/00062752-199502060-00005. PMID: 9372031

Prognosis

Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Yuki H, Kikuzato K, Koda Y, Mikuni J, Tomabechi Y, Kukimoto-Niino M, Tanaka A, Shirai F, Shirouzu M, Koyama H, Honma T
Bioorg Med Chem 2017 Aug 15;25(16):4259-4264. Epub 2017 Jun 16 doi: 10.1016/j.bmc.2017.05.053. PMID: 28662963
Acute basophilic leukemia.
Giagounidis AA, Hildebrandt B, Heinsch M, Germing U, Aivado M, Aul C
Eur J Haematol 2001 Aug;67(2):72-6. doi: 10.1034/j.1600-0609.2001.t01-1-00487.x. PMID: 11722593
Neoplastic meningitis: diagnosis and treatment considerations.
Blaney SM, Poplack DG
Med Oncol 2000 Aug;17(3):151-62. doi: 10.1007/BF02780522. PMID: 10962524
Allogeneic bone marrow transplantation.
Weiden PL
Crit Rev Clin Lab Sci 1983;19(3):173-86. doi: 10.3109/10408368309165762. PMID: 6373140
Long-term stable hematopoietic chimerism following marrow transplantation for acute lymphoblastic leukemia: a case report with in vitro marrow culture studies.
Singer JW, Keating A, Ramberg R, McGuffin R, Sanders JE, Sale G, Fialkow PJ, Thomas ED
Blood 1983 Oct;62(4):869-72. PMID: 6349717

Clinical prediction guides

Utilization of supportive care medications and opportunities for pre-emptive pharmacogenomic testing in pediatric and young adults with leukemia.
Sakon CM, Sales C, Mertami S, Raibulet A, Schulte RR, Slaven JE, Tillman EM
Pediatr Hematol Oncol 2024 Oct;41(7):480-488. Epub 2024 Jun 21 doi: 10.1080/08880018.2024.2368007. PMID: 38904214Free PMC Article
Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Yuki H, Kikuzato K, Koda Y, Mikuni J, Tomabechi Y, Kukimoto-Niino M, Tanaka A, Shirai F, Shirouzu M, Koyama H, Honma T
Bioorg Med Chem 2017 Aug 15;25(16):4259-4264. Epub 2017 Jun 16 doi: 10.1016/j.bmc.2017.05.053. PMID: 28662963
Antibody-targeted chemotherapy of acute myeloid leukemia using gemtuzumab ozogamicin (Mylotarg).
Sievers EL
Blood Cells Mol Dis 2003 Jul-Aug;31(1):7-10. doi: 10.1016/s1079-9796(03)00117-7. PMID: 12850477
Acute basophilic leukemia.
Giagounidis AA, Hildebrandt B, Heinsch M, Germing U, Aivado M, Aul C
Eur J Haematol 2001 Aug;67(2):72-6. doi: 10.1034/j.1600-0609.2001.t01-1-00487.x. PMID: 11722593
Donor leukocyte transfusions for leukemic relapse.
van Rhee F, Kolb HJ
Curr Opin Hematol 1995 Nov;2(6):423-30. doi: 10.1097/00062752-199502060-00005. PMID: 9372031

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