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Non-functioning endocrine neoplasm

MedGen UID:
458882
Concept ID:
C2986656
Neoplastic Process
Synonyms: endocrine-inactive tumor; endocrine-inactive tumour; Non-Functioning Endocrine Neoplasm; non-functioning endocrine neoplasm; Nonfunctional Endocrine Neoplasm; nonfunctional Endocrine neoplasm; Nonfunctioning Endocrine Neoplasm; nonfunctioning tumor; nonfunctioning tumour
 
Monarch Initiative: MONDO:0021119

Definition

A hormone producing or non-producing endocrine neoplasm, not associated with a hormonal syndrome. [from NCI]

Professional guidelines

PubMed

Prete A, Bancos I
Nat Rev Endocrinol 2024 Aug;20(8):460-473. Epub 2024 Apr 22 doi: 10.1038/s41574-024-00984-y. PMID: 38649778
Korbonits M, Blair JC, Boguslawska A, Ayuk J, Davies JH, Druce MR, Evanson J, Flanagan D, Glynn N, Higham CE, Jacques TS, Sinha S, Simmons I, Thorp N, Swords FM, Storr HL, Spoudeas HA
Nat Rev Endocrinol 2024 May;20(5):290-309. Epub 2024 Feb 9 doi: 10.1038/s41574-023-00949-7. PMID: 38336898
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284

Recent clinical studies

Etiology

Kos-Kudła B, Castaño JP, Denecke T, Grande E, Kjaer A, Koumarianou A, de Mestier L, Partelli S, Perren A, Stättner S, Valle JW, Fazio N
J Neuroendocrinol 2023 Dec;35(12):e13343. Epub 2023 Oct 25 doi: 10.1111/jne.13343. PMID: 37877341
Aresta C, Favero V, Morelli V, Giovanelli L, Parazzoli C, Falchetti A, Pugliese F, Gennari L, Vescini F, Salcuni A, Scillitani A, Persani L, Chiodini I
Best Pract Res Clin Endocrinol Metab 2021 Mar;35(2):101494. Epub 2021 Feb 23 doi: 10.1016/j.beem.2021.101494. PMID: 33814301
Øystese KA, Evang JA, Bollerslev J
Endocrine 2016 Jul;53(1):28-34. Epub 2016 Apr 11 doi: 10.1007/s12020-016-0940-7. PMID: 27066792
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Lazaro CM, Guo WY, Sami M, Hindmarsh T, Ericson K, Hulting AL, Wersäll J
Neuroradiology 1994;36(2):111-4. doi: 10.1007/BF00588072. PMID: 8183446

Diagnosis

Prete A, Bancos I
Nat Rev Endocrinol 2024 Aug;20(8):460-473. Epub 2024 Apr 22 doi: 10.1038/s41574-024-00984-y. PMID: 38649778
Kos-Kudła B, Castaño JP, Denecke T, Grande E, Kjaer A, Koumarianou A, de Mestier L, Partelli S, Perren A, Stättner S, Valle JW, Fazio N
J Neuroendocrinol 2023 Dec;35(12):e13343. Epub 2023 Oct 25 doi: 10.1111/jne.13343. PMID: 37877341
Aresta C, Favero V, Morelli V, Giovanelli L, Parazzoli C, Falchetti A, Pugliese F, Gennari L, Vescini F, Salcuni A, Scillitani A, Persani L, Chiodini I
Best Pract Res Clin Endocrinol Metab 2021 Mar;35(2):101494. Epub 2021 Feb 23 doi: 10.1016/j.beem.2021.101494. PMID: 33814301
Niederle B, Selberherr A, Bartsch DK, Brandi ML, Doherty GM, Falconi M, Goudet P, Halfdanarson TR, Ito T, Jensen RT, Larghi A, Lee L, Öberg K, Pavel M, Perren A, Sadowski SM, Tonelli F, Triponez F, Valk GD, O'Toole D, Scott-Coombes D, Thakker RV, Thompson GB, Treglia G, Wiedenmann B
Neuroendocrinology 2021;111(7):609-630. Epub 2020 Sep 24 doi: 10.1159/000511791. PMID: 32971521
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284

Therapy

Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Partelli S, Massironi S, Zerbi A, Niccoli P, Kwon W, Landoni L, Panzuto F, Tomazic A, Bongiovanni A, Kaltsas G, Sauvanet A, Bertani E, Mazzaferro V, Caplin M, Armstrong T, Weickert MO, Ramage J, Segelov E, Butturini G, Staettner S, Cives M, Frilling A, Moulton CA, He J, Boesch F, Selberheer A, Twito O, Castaldi A, De Angelis CG, Gaujoux S, Holzer K, Wilson CH, Almeamar H, Vigia E, Muffatti F, Lucà M, Lania A, Ewald J, Kim H, Salvia R, Rinzivillo M, Smid A, Gardini A, Tsoli M, Hentic O, Colombo S, Citterio D, Toumpanakis C, Ramsey E, Randeva HS, Srirajaskanthan R, Croagh D, Regi P, Gasteiger S, Invernizzi P, Ridolfi C, Giovannini M, Jang JY, Bassi C, Falconi M
Br J Surg 2022 Nov 22;109(12):1186-1190. doi: 10.1093/bjs/znac267. PMID: 35986682Free PMC Article
Park BK
Endocrinol Metab (Seoul) 2020 Dec;35(4):750-755. Epub 2020 Dec 2 doi: 10.3803/EnM.2020.880. PMID: 33261308Free PMC Article
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Greenman Y, Stern N
Endocrine 2015 Sep;50(1):51-5. Epub 2015 Jul 16 doi: 10.1007/s12020-015-0685-8. PMID: 26179179

Prognosis

Aresta C, Favero V, Morelli V, Giovanelli L, Parazzoli C, Falchetti A, Pugliese F, Gennari L, Vescini F, Salcuni A, Scillitani A, Persani L, Chiodini I
Best Pract Res Clin Endocrinol Metab 2021 Mar;35(2):101494. Epub 2021 Feb 23 doi: 10.1016/j.beem.2021.101494. PMID: 33814301
Niederle B, Selberherr A, Bartsch DK, Brandi ML, Doherty GM, Falconi M, Goudet P, Halfdanarson TR, Ito T, Jensen RT, Larghi A, Lee L, Öberg K, Pavel M, Perren A, Sadowski SM, Tonelli F, Triponez F, Valk GD, O'Toole D, Scott-Coombes D, Thakker RV, Thompson GB, Treglia G, Wiedenmann B
Neuroendocrinology 2021;111(7):609-630. Epub 2020 Sep 24 doi: 10.1159/000511791. PMID: 32971521
Ben-Shlomo A, Cooper O
Pituitary 2018 Apr;21(2):183-193. doi: 10.1007/s11102-018-0864-8. PMID: 29344907
Øystese KA, Evang JA, Bollerslev J
Endocrine 2016 Jul;53(1):28-34. Epub 2016 Apr 11 doi: 10.1007/s12020-016-0940-7. PMID: 27066792
Kuo JH, Lee JA, Chabot JA
Surg Clin North Am 2014 Jun;94(3):689-708. Epub 2014 Apr 13 doi: 10.1016/j.suc.2014.02.010. PMID: 24857584

Clinical prediction guides

Pelsma ICM, Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Oct 17;189(4):S88-S101. doi: 10.1093/ejendo/lvad134. PMID: 37801655
Aresta C, Favero V, Morelli V, Giovanelli L, Parazzoli C, Falchetti A, Pugliese F, Gennari L, Vescini F, Salcuni A, Scillitani A, Persani L, Chiodini I
Best Pract Res Clin Endocrinol Metab 2021 Mar;35(2):101494. Epub 2021 Feb 23 doi: 10.1016/j.beem.2021.101494. PMID: 33814301
Deguelte S, de Mestier L, Hentic O, Cros J, Lebtahi R, Hammel P, Kianmanesh R
J Visc Surg 2018 Dec;155(6):483-492. Epub 2018 Nov 15 doi: 10.1016/j.jviscsurg.2018.08.010. PMID: 30448206
Frohman LA, Eguchi K
Growth Horm IGF Res 2004 Jun;14 Suppl A:S90-6. doi: 10.1016/j.ghir.2004.03.021. PMID: 15135786
Gittoes NJ
Pituitary 2003 Sep;6(2):103-8. doi: 10.1023/b:pitu.0000004801.95086.e2. PMID: 14703020

Recent systematic reviews

Pelsma ICM, Fassnacht M, Tsagarakis S, Terzolo M, Tabarin A, Sahdev A, Newell-Price J, Marina L, Lorenz K, Bancos I, Arlt W, Dekkers OM
Eur J Endocrinol 2023 Oct 17;189(4):S88-S101. doi: 10.1093/ejendo/lvad134. PMID: 37801655
Rikvold SD, Pedersen MB, Andreassen M, Krogh J
Horm Metab Res 2023 Jul;55(7):443-451. Epub 2023 Jul 10 doi: 10.1055/a-2096-1340. PMID: 37494058
Botelho MS, Franzini ÍA, Nunes-Nogueira VDS, Boguszewski CL
Pituitary 2022 Dec;25(6):810-818. Epub 2022 Jul 28 doi: 10.1007/s11102-022-01257-5. PMID: 35902444
Hosseinkhan N, Honardoost M, Emami Z, Cheraghi S, Hashemi-Madani N, Khamseh ME
Endocrine 2022 Sep;77(3):500-509. Epub 2022 Jun 16 doi: 10.1007/s12020-022-03105-9. PMID: 35711030
Chen CC, Carter BS, Wang R, Patel KS, Hess C, Bodach ME, Tumialan LM, Oyesiku NM, Patil CG, Litvack Z, Zada G, Aghi MK
Neurosurgery 2016 Oct;79(4):E524-6. doi: 10.1227/NEU.0000000000001391. PMID: 27635958

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